Hippo signaling: A hub of growth control, tumor suppression and pluripotency maintenance
文献类型：期刊论文
| 作者 | Yin, MX; Zhang, L |
| 刊名 | JOURNAL OF GENETICS AND GENOMICS
 |
| 出版日期 | 2011 |
| 卷号 | 38期号:10页码:471-481 |
| 关键词 | Cell signaling Crosstalk Development Drosophila Hippo Organ size control Stem cell Tumorigenesis |
| 通讯作者 | Zhang, L (reprint author), Chinese Acad Sci, State Key Lab Cell Biol, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, 320 Yueyang Rd, Shanghai 200031, Peoples R China.,rayzhang@sibs.ac.cn |
| 英文摘要 | The molecular mechanisms of organ size control and regulation remain one of the major unsolved mysteries of development biology. Almost a decade ago, the discovery of the Hippo signaling pathway in Drosophila shed some light on this puzzling issue. The Hippo signaling pathway is highly conserved in both invertebrates and vertebrates, and plays critical roles in animal development. It controls organ size and growth by inhibiting cell proliferation and by promoting apoptosis. Malfunction of the Hippo signaling pathway leads to cancer development and tumorigenesis. Although the core of the signaling pathway is well understood, the upstream inputs and downstream transcriptional regulation are still obscure to us. In this review, we summarize the current understanding of the mechanism and the function of the Hippo signaling pathway and compare its differences between flies and mammals. We underline the crosstalk between the Hippo signaling pathway and other signaling pathways, and the possible roles of the Hippo pathway in stem cell proliferation and self-renewal. |
| 学科主题 | Biochemistry & Molecular Biology; Genetics & Heredity |
| 类目[WOS] | Biochemistry & Molecular Biology ; Genetics & Heredity |
| 关键词[WOS] | YES-ASSOCIATED PROTEIN ; ORGAN SIZE CONTROL ; EPITHELIAL-MESENCHYMAL TRANSITION ; MESSENGER-RNA EXPRESSION ; PLANAR-CELL-POLARITY ; WW DOMAIN ; TRANSCRIPTIONAL COACTIVATOR ; DROSOPHILA HOMOLOG ; PROMOTES APOPTOSIS ; CONTACT INHIBITION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000296531800006 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/855]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Yin, MX,Zhang, L. Hippo signaling: A hub of growth control, tumor suppression and pluripotency maintenance[J]. JOURNAL OF GENETICS AND GENOMICS,2011,38(10):471-481. |
| APA | Yin, MX,&Zhang, L.(2011).Hippo signaling: A hub of growth control, tumor suppression and pluripotency maintenance.JOURNAL OF GENETICS AND GENOMICS,38(10),471-481. |
| MLA | Yin, MX,et al."Hippo signaling: A hub of growth control, tumor suppression and pluripotency maintenance".JOURNAL OF GENETICS AND GENOMICS 38.10(2011):471-481. |
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