Postischemic administration of liposome-encapsulated luteolin prevents against ischemia-reperfusion injury in a rat middle cerebral artery occlusion model
文献类型：期刊论文
| 作者 | Zhao, G; Zang, SY; Jiang, ZH; Chen, YY; Ji, XH; Lu, BF; Wu, JH; Qin, GW; Guo, LH |
| 刊名 | JOURNAL OF NUTRITIONAL BIOCHEMISTRY
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| 出版日期 | 2011 |
| 卷号 | 22期号:10页码:929-936 |
| 关键词 | Reactive oxygen species Luteolin Neuroprotectant Ischemia Reperfusion Oxidant-antioxidant balance |
| 通讯作者 | Guo, LH (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China.,zhaogangtcm@hotmail.com ; lhguo@sibs.ac.cn |
| 英文摘要 | Oxidative stress-induced neuronal cell death has been implicated in neurodegenerative diseases; one such disease is ischemic stroke. Using reactive oxygen species (ROS)-insulted primary neurons, we screened neuroprotectants with clinical potential and then, using ischemia/reperfusion (I/R) model, investigated the anti-ischemic potential of candidate neuroprotectants. Here, we showed that luteolin, isolated from the ripe fruit of Perilla frutescens (L) Britt, exhibited a neuroprotective action upon the in vitro platform, thus serving as candidate for in vivo pharmacological evaluation. Liposome-encapsulated luteolin produced dramatic preventing effects on I/R-induced behavioral and histological injuries after a 13-day post-ischemic treatment. Furthermore, this phytochemical not only lowered the increased level of mitochondria' ROS but also substantially up-regulated the decreased activity of catalase and glutathione in I/R rat brains. Collectively, luteolin as a neuroprotectant acts by anti-ischemic activity likely through a rebalancing of pro-oxidant/antioxidant status. Its multitarget mechanisms implicate potential effectiveness for clinically treating ischemia stroke. (C) 2011 Elsevier Inc. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology; Nutrition & Dietetics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Nutrition & Dietetics |
| 关键词[WOS] | HUMAN ENDOTHELIAL-CELLS ; NECROSIS-FACTOR-ALPHA ; OXIDATIVE STRESS ; ANTIOXIDANT STATUS ; INDUCED TOXICITY ; NEURONAL INJURY ; GENE-EXPRESSION ; KAPPA-B ; STROKE ; BRAIN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000295606100005 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/857]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhao, G,Zang, SY,Jiang, ZH,et al. Postischemic administration of liposome-encapsulated luteolin prevents against ischemia-reperfusion injury in a rat middle cerebral artery occlusion model[J]. JOURNAL OF NUTRITIONAL BIOCHEMISTRY,2011,22(10):929-936. |
| APA | Zhao, G.,Zang, SY.,Jiang, ZH.,Chen, YY.,Ji, XH.,...&Guo, LH.(2011).Postischemic administration of liposome-encapsulated luteolin prevents against ischemia-reperfusion injury in a rat middle cerebral artery occlusion model.JOURNAL OF NUTRITIONAL BIOCHEMISTRY,22(10),929-936. |
| MLA | Zhao, G,et al."Postischemic administration of liposome-encapsulated luteolin prevents against ischemia-reperfusion injury in a rat middle cerebral artery occlusion model".JOURNAL OF NUTRITIONAL BIOCHEMISTRY 22.10(2011):929-936. |
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