Transformation of human amniotic epithelial cells into neuron-like cells in the microenvironment of traumatic brain injury in vivo and in vitro
文献类型：期刊论文
| 作者 | Lu, Y; Hui, GZ; Wu, ZY; Liu, TJ; Ji, XH; Guo, LH |
| 刊名 | NEURAL REGENERATION RESEARCH
 |
| 出版日期 | 2011 |
| 卷号 | 6期号:10页码:744-749 |
| 关键词 | traumatic brain injury microenvironment transplantation human amniotic epithelial cells neural cell differentiation neural regeneration |
| 通讯作者 | Hui, GZ (reprint author), Soochow Univ, Affiliated Hosp 1, Dept Neurosurg, Suzhou 215006, Jiangsu Provice, Peoples R China.,guozhen-hui@163.com |
| 英文摘要 | Survival and differentiation of transplanted cells is closely related to the local microenvironment. The present study cultured human amniotic epithelial cells (HAECs) in a simulated microenvironment in vitro comprising RPMI 1640 culture medium and the solution extracted from injured brain tissues. Some HAECs were round, triangular in form or irregularly shaped, with extended neuron-like processes; some of the processes were interconnected, representing neuron-like morphology and some HAECs were microtubule-associated protein 2-positive. HAECs survived for at least 4 weeks following transplantation into the center and edges of the trauma focus with traumatic brain injury, and were microtubule-associated protein 2-positive. Moreover, the motor function of rat hind limbs was significantly improved. |
| 学科主题 | Cell Biology; Neurosciences & Neurology |
| 类目[WOS] | Cell Biology ; Neurosciences |
| 关键词[WOS] | STEM-CELLS ; PARKINSONS-DISEASE ; RAT ; TRANSPLANTATION ; THERAPY ; EXPRESSION ; CATECHOLAMINES ; DIFFERENTIATE ; REPLACEMENT ; PRECURSORS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000291416000004 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/863]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Lu, Y,Hui, GZ,Wu, ZY,et al. Transformation of human amniotic epithelial cells into neuron-like cells in the microenvironment of traumatic brain injury in vivo and in vitro[J]. NEURAL REGENERATION RESEARCH,2011,6(10):744-749. |
| APA | Lu, Y,Hui, GZ,Wu, ZY,Liu, TJ,Ji, XH,&Guo, LH.(2011).Transformation of human amniotic epithelial cells into neuron-like cells in the microenvironment of traumatic brain injury in vivo and in vitro.NEURAL REGENERATION RESEARCH,6(10),744-749. |
| MLA | Lu, Y,et al."Transformation of human amniotic epithelial cells into neuron-like cells in the microenvironment of traumatic brain injury in vivo and in vitro".NEURAL REGENERATION RESEARCH 6.10(2011):744-749. |
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