beta-Arrestin-1 Protein Represses Diet-induced Obesity
文献类型：期刊论文
| 作者 | Zhuang, LN; Hu, WX; Zhang, ML; Xin, SM; Jia, WP; Zhao, J; Pei, G |
| 刊名 | JOURNAL OF BIOLOGICAL CHEMISTRY
 |
| 出版日期 | 2011 |
| 卷号 | 286期号:32页码:28396-28402 |
| 通讯作者 | Pei, G (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,gpei@sibs.ac.cn |
| 英文摘要 | Diet-related obesity is a major metabolic disorder. Excessive fat mass is associated with type 2 diabetes, hepatic steatosis, and arteriosclerosis. Dysregulation of lipid metabolism and adipose tissue function contributes to diet-induced obesity. Here, we report that beta-arrestin-1 knock-out mice are susceptible to diet-induced obesity. Knock-out of the gene encoding beta-arrestin-1 caused increased fat mass accumulation and decreased whole-body insulin sensitivity in mice fed a high-fat diet. In beta-arrestin-1 knock-out mice, we observed disrupted food intake and energy expenditure and increased macrophage infiltration in white adipose tissue. At the molecular level, beta-arrestin-1 deficiency affected the expression of many lipid metabolic genes and inflammatory genes in adipose tissue. Consistently, transgenic overexpression of beta-arrestin-1 repressed diet-induced obesity and improved glucose tolerance and systemic insulin sensitivity. Thus, our findings reveal that beta-arrestin-1 plays a role in metabolism regulation. |
| 学科主题 | Biochemistry & Molecular Biology |
| 类目[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | INSULIN-RESISTANCE ; ENERGY-BALANCE ; BETA-ARRESTIN ; PPAR-GAMMA ; RAT-BRAIN ; FAT ; ACTIVATION ; PHOSPHORYLATION ; CONTRIBUTES ; SENSITIVITY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000293557800055 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/888]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhuang, LN,Hu, WX,Zhang, ML,et al. beta-Arrestin-1 Protein Represses Diet-induced Obesity[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2011,286(32):28396-28402. |
| APA | Zhuang, LN.,Hu, WX.,Zhang, ML.,Xin, SM.,Jia, WP.,...&Pei, G.(2011).beta-Arrestin-1 Protein Represses Diet-induced Obesity.JOURNAL OF BIOLOGICAL CHEMISTRY,286(32),28396-28402. |
| MLA | Zhuang, LN,et al."beta-Arrestin-1 Protein Represses Diet-induced Obesity".JOURNAL OF BIOLOGICAL CHEMISTRY 286.32(2011):28396-28402. |
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