Upregulation of pancreatic derived factor (FAM3B) expression in pancreatic beta-cells by MCP-1 (CCL2)
文献类型：期刊论文
| 作者 | Hou, XW; Wang, OM; Li, ZM; Mou, HW; Chen, J; Deng, B; Qian, LH; Liu, XL; Le, YY |
| 刊名 | MOLECULAR AND CELLULAR ENDOCRINOLOGY
 |
| 出版日期 | 2011 |
| 卷号 | 343期号:1页码:18-24 |
| 关键词 | CCL2 Pancreatic derived factor FAM3B Pancreatic islet beta-Cell Signal transduction |
| 通讯作者 | Le, YY (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Grad Sch, Key Lab Nutr & Metab, Shanghai, Peoples R China.,yyle@sibs.ac.cn |
| 英文摘要 | Pancreatic derived factor (PANDER, FAM3B) is a peptide mainly synthesized and secreted by pancreatic beta-cells. PANDER is proposed to be involved in regulation of beta-cell function under physiological conditions and impairment of beta-cell function under pathological conditions. MCP-1 (CCL2) is expressed by normal pancreatic islets and has been implicated in inflammation related pancreatic disorders. We examined the effect of MCP-1 on PANDER expression by using murine pancreatic beta-cell line MIN6 and pancreatic islets. We found that MCP-1 induced PANDER mRNA transcription and protein synthesis in MIN6 cells and islets. By using calcium chelator (EGTA); inhibitors for PKC (Go6976), MEK1/2 (PD98059) or c-Jun-N-terminal kinase (JNK) (SP600125); c-Jun dominant-negative construct; PANDER promoter luciferase constructs; and islets isolated from Fos knockout mice; we demonstrated that MCP-1 induced PANDER gene expression in beta-cells through Ca(2+)-ERK1/2-AP-1 and PKC-JNK-AP-1 signaling pathways. Our findings suggest a new link between the endocrine and immune systems and provide useful information for further investigating the physiological functions of PANDER and its involvement in inflammation-related pancreatic disorders. (C) 2011 Elsevier Ireland Ltd. All rights reserved. |
| 学科主题 | Cell Biology; Endocrinology & Metabolism |
| 类目[WOS] | Cell Biology ; Endocrinology & Metabolism |
| 关键词[WOS] | MONOCYTE CHEMOATTRACTANT PROTEIN-1 ; FACTOR-KAPPA-B ; FACTOR PANDER ; ISLET TRANSPLANTATION ; OBESE SUBJECTS ; KINASE-C ; IN-VITRO ; ACTIVATION ; GENE ; GLUCOSE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000295349200003 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/899]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Hou, XW,Wang, OM,Li, ZM,et al. Upregulation of pancreatic derived factor (FAM3B) expression in pancreatic beta-cells by MCP-1 (CCL2)[J]. MOLECULAR AND CELLULAR ENDOCRINOLOGY,2011,343(1):18-24. |
| APA | Hou, XW.,Wang, OM.,Li, ZM.,Mou, HW.,Chen, J.,...&Le, YY.(2011).Upregulation of pancreatic derived factor (FAM3B) expression in pancreatic beta-cells by MCP-1 (CCL2).MOLECULAR AND CELLULAR ENDOCRINOLOGY,343(1),18-24. |
| MLA | Hou, XW,et al."Upregulation of pancreatic derived factor (FAM3B) expression in pancreatic beta-cells by MCP-1 (CCL2)".MOLECULAR AND CELLULAR ENDOCRINOLOGY 343.1(2011):18-24. |
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