Comprehensive analysis of clinical significance of stem-cell related factors in renal cell cancer
文献类型：期刊论文
| 作者 | Liu, YC; Zhang, CC; Fan, J; Xiao, L; Yin, BD; Zhou, LB; Xia, SJ |
| 刊名 | WORLD JOURNAL OF SURGICAL ONCOLOGY
 |
| 出版日期 | 2011 |
| 卷号 | 9期号:1页码:121-121 |
| 关键词 | c-MYC LIN28 KLF4 SOX2 OCT4 NANOG Kidney Neoplasm |
| 通讯作者 | Fan, J (reprint author), Shanghai Jiao Tong Univ, Sch Med, Shanghai Peoples Hosp 1, Dept Urol, Shanghai 200080, Peoples R China.,jief67@sina.com |
| 英文摘要 | Background: C-MYC, LIN28, OCT4, KLF4, NANOG and SOX2 are stem cell related factors. We detected whether these factors express in renal cell carcinoma (RCC) tissues to study their correlations with the clinical and pathological characteristics. Methods: The expressions of c-MYC, LIN28, SOX2, KLF4, OCT4 and NANOG in 30 RCC patients and 5 non-RCC patients were detected with quantitative real-time reverse transcription-PCR (qRT-PCR). The data were analyzed with Wilcoxon signed rank sum test and x(2) test. Results: In RCC group, c-MYC expression was significantly higher in RCC tissues compared with normal tissues (P < 0.05). The expression levels of OCT4, KLF4, NANOG and SOX2 were significantly lower in RCC tissues compared with normal tissues (P < 0.05). LIN28 expression level was not significant. No difference was observed when it comes to clinical and pathological characteristics such as gender, age, tumor size, cTNM classification and differentiation status (P > 0.05). Also the expression levels of all above factors were not significantly changed in non-RCC group (P > 0.05). Conclusions: The present analysis strongly suggests that altered expression of several stem cell related factors may play different roles in RCC. C-MYC may function as an oncogene and OCT4, KLF4, NANOG and SOX2 as tumor suppressors. |
| 学科主题 | Oncology; Surgery |
| 类目[WOS] | Oncology ; Surgery |
| 关键词[WOS] | CARCINOMA-CELLS ; EXPRESSION ; MYC ; PROLIFERATION ; LIN28 ; GENE ; KLF4 ; IDENTIFICATION ; TRANSFORMATION ; TUMORIGENESIS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000296745300001 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/903]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Liu, YC,Zhang, CC,Fan, J,et al. Comprehensive analysis of clinical significance of stem-cell related factors in renal cell cancer[J]. WORLD JOURNAL OF SURGICAL ONCOLOGY,2011,9(1):121-121. |
| APA | Liu, YC.,Zhang, CC.,Fan, J.,Xiao, L.,Yin, BD.,...&Xia, SJ.(2011).Comprehensive analysis of clinical significance of stem-cell related factors in renal cell cancer.WORLD JOURNAL OF SURGICAL ONCOLOGY,9(1),121-121. |
| MLA | Liu, YC,et al."Comprehensive analysis of clinical significance of stem-cell related factors in renal cell cancer".WORLD JOURNAL OF SURGICAL ONCOLOGY 9.1(2011):121-121. |
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