SRMBUILDER: A USER-FRIENDLY TOOL FOR SELECTED REACTION MONITORING DATA ANALYSIS
文献类型：期刊论文
| 作者 | Sheng, QH; Wu, CC; Su, ZD; Zeng, R |
| 刊名 | JOURNAL OF BIOINFORMATICS AND COMPUTATIONAL BIOLOGY
 |
| 出版日期 | 2011 |
| 卷号 | 9期号:1页码:51-62 |
| 关键词 | SRM SRMBuilder quantification mass spectrometry targeted proteomics |
| 通讯作者 | Sheng, QH (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Key Lab Syst Biol, Shanghai, Peoples R China.,qhsheng@sibs.ac.cn ; ccwu@sibs.ac.cn ; suzhiduan@sibs.ac.cn ; zr@sibs.ac.cn |
| 英文摘要 | With high sensitivity and reproducibility, selected reaction monitoring (SRM) has become increasingly popular in proteome research for targeted quantification of low abundance proteins and post translational modification. SRM is also well accepted in other mass-spectrometry based research areas such as lipidomics and metabolomics, which necessitates the development of easy-to-use software for both post-acquisition SRM data analysis and quantification result validation. Here, we introduce a software tool SRMBuilder, which can automatically parse SRM data in multiple file formats, assign transitions to compounds, match light/heavy transition/compound pairs and provide a user-friendly graphic interface to manually validate the quantification result at transition/compound/sample level. SRMBuilder will greatly facilitate processing of the post-acquisition data files and validation of quantification result for SRM. The software can be downloaded for free from http://www.proteomics.ac.cn/software/proteomicstools/index.htm as part of the software suite ProteomicsTools. |
| 学科主题 | Biochemistry & Molecular Biology; Computer Science; Mathematical & Computational Biology |
| 类目[WOS] | Biochemical Research Methods ; Computer Science, Interdisciplinary Applications ; Mathematical & Computational Biology |
| 关键词[WOS] | TANDEM MASS-SPECTROMETRY ; PROTEOMICS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000299290400005 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/907]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Sheng, QH,Wu, CC,Su, ZD,et al. SRMBUILDER: A USER-FRIENDLY TOOL FOR SELECTED REACTION MONITORING DATA ANALYSIS[J]. JOURNAL OF BIOINFORMATICS AND COMPUTATIONAL BIOLOGY,2011,9(1):51-62. |
| APA | Sheng, QH,Wu, CC,Su, ZD,&Zeng, R.(2011).SRMBUILDER: A USER-FRIENDLY TOOL FOR SELECTED REACTION MONITORING DATA ANALYSIS.JOURNAL OF BIOINFORMATICS AND COMPUTATIONAL BIOLOGY,9(1),51-62. |
| MLA | Sheng, QH,et al."SRMBUILDER: A USER-FRIENDLY TOOL FOR SELECTED REACTION MONITORING DATA ANALYSIS".JOURNAL OF BIOINFORMATICS AND COMPUTATIONAL BIOLOGY 9.1(2011):51-62. |
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