IFN-gamma Triggered STAT1-PKB/AKT Signalling Pathway Influences the Function of Alloantigen Reactive Regulatory T Cells
文献类型：期刊论文
| 作者 | Wei, B; Baker, S; Wieckiewicz, J; Wood, KJ |
| 刊名 | AMERICAN JOURNAL OF TRANSPLANTATION
 |
| 出版日期 | 2010 |
| 卷号 | 10期号:1页码:69-80 |
| 关键词 | Akt survival pathway allograft survival interferon gamma (IFN-gamma) regulatory T cells STAT-1 |
| 通讯作者 | Wei, B (reprint author), Chinese Acad Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, Shanghai 200031, Peoples R China.,weibin@sibs.ac.cn ; kathryn.wood@nds.ox.ac.uk |
| 英文摘要 | CD4+CD25+Foxp3+ regulatory T cells (Tregs) play a key role in the induction and maintenance of peripheral tolerance. Rapid and transient production of IFN-gamma by Tregs from mice tolerized to alloantigen in vivo has been shown to be critical for their regulatory function. This IFN-gamma has the potential to affect the function of cells present in the same local microenvironment as the Tregs, including the Tregs themselves. Here we investigated the mechanism by which IFN-gamma produced by Tregs triggered signaling pathways in alloantigen reactive Tregs themselves thereby influencing their function in vivo. We show that IFN-gamma production and STAT1 activation was increased, while STAT1-dependent PKB/AKT activation was downregulated in alloantigen reactive Tregs. Further, the activation of STAT1 was blocked in IFN-gamma receptor deficient as well as IFN-gamma-deficient Tregs, suggesting that IFN-gamma produced by the alloantigen reactive Tregs might act in an autocrine manner to induce STAT1 activation. Importantly, STAT1-deficient Tregs failed to control allograft rejection in vivo. Overall, these findings suggest that the IFN-gamma-induced STAT1-PKB/AKT signaling pathway plays a key role in upregulating the ability of alloantigen reactive Tregs to control graft rejection in vivo. |
| 学科主题 | Surgery; Transplantation |
| 类目[WOS] | Surgery ; Transplantation |
| 关键词[WOS] | IN-VIVO ; TRANSPLANTATION TOLERANCE ; ALLOGRAFT-REJECTION ; FOXP3 EXPRESSION ; STAT1 ; RECEPTOR ; INHIBITION ; ACTIVATION ; DISTINCT ; MTOR |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000272882000013 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/925]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Wei, B,Baker, S,Wieckiewicz, J,et al. IFN-gamma Triggered STAT1-PKB/AKT Signalling Pathway Influences the Function of Alloantigen Reactive Regulatory T Cells[J]. AMERICAN JOURNAL OF TRANSPLANTATION,2010,10(1):69-80. |
| APA | Wei, B,Baker, S,Wieckiewicz, J,&Wood, KJ.(2010).IFN-gamma Triggered STAT1-PKB/AKT Signalling Pathway Influences the Function of Alloantigen Reactive Regulatory T Cells.AMERICAN JOURNAL OF TRANSPLANTATION,10(1),69-80. |
| MLA | Wei, B,et al."IFN-gamma Triggered STAT1-PKB/AKT Signalling Pathway Influences the Function of Alloantigen Reactive Regulatory T Cells".AMERICAN JOURNAL OF TRANSPLANTATION 10.1(2010):69-80. |
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