The serine/threonine kinase LKB1 controls thymocyte survival through regulation of AMPK activation and Bcl-XL expression
文献类型：期刊论文
| 作者 | Cao, YH; Li, H; Liu, HF; Zheng, C; Ji, HB; Liu, XL |
| 刊名 | CELL RESEARCH
 |
| 出版日期 | 2010 |
| 卷号 | 20期号:1页码:99-108 |
| 关键词 | LKB1 AMPK Bcl-XL thymocyte survival development |
| 通讯作者 | Liu, XL (reprint author), Chinese Acad Sci, Mol Cell Biol Lab, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China.,liux@sibs.ac.cn |
| 英文摘要 | LKB1 is a serine/threonine kinase that directly activates the energy sensor AMP-activated protein kinase (AMPK) in response to bioenergetic stress, and mainly acts as a tumor suppressor that controls cell polarity and proliferation. Although LKB1 is expressed in multiple tissues including the thymus and the spleen, its roles in T-cell development and function remain unknown. Here, we show that T-cell-specific deletion of LKB1 resulted in reduced survival of double-positive (DP) thymocytes and impaired generation of both CD4 and CD8 single-positive thymocytes. Disruption of LKB1 not only prevented the activation of AMPK but also impaired the expression of anti-apoptotic protein Bcl-XL. Importantly, ectopic expression of either Bcl-XL or the constitutively active AMPK mutant significantly rescued DP thymocytes from LKB1 deficiency-induced cell death. Moreover, ectopic expression of the constitutively active AMPK mutant was found to restore the expression of Bcl-XL in LKB1-deficient DP thymocytes. These findings identify LKB1 as a critical factor for the survival of DP thymocytes through regulation of AMPK activation and Bcl-XL expression. |
| 学科主题 | Cell Biology |
| 类目[WOS] | Cell Biology |
| 关键词[WOS] | T-CELL-RECEPTOR ; PROTEIN-KINASE ; TUMOR-SUPPRESSOR ; POSITIVE SELECTION ; ANTIGEN RECEPTOR ; BETA-SELECTION ; TCR SIGNALS ; ROR-GAMMA ; METABOLISM ; GENE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000273790500011 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/930]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Cao, YH,Li, H,Liu, HF,et al. The serine/threonine kinase LKB1 controls thymocyte survival through regulation of AMPK activation and Bcl-XL expression[J]. CELL RESEARCH,2010,20(1):99-108. |
| APA | Cao, YH,Li, H,Liu, HF,Zheng, C,Ji, HB,&Liu, XL.(2010).The serine/threonine kinase LKB1 controls thymocyte survival through regulation of AMPK activation and Bcl-XL expression.CELL RESEARCH,20(1),99-108. |
| MLA | Cao, YH,et al."The serine/threonine kinase LKB1 controls thymocyte survival through regulation of AMPK activation and Bcl-XL expression".CELL RESEARCH 20.1(2010):99-108. |
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