Nmnat2 delays axon degeneration in superior cervical ganglia dependent on its NAD synthesis activity
文献类型：期刊论文
| 作者 | Yan, TT; Feng, Y; Zheng, J; Ge, XJ; Zhang, Y; Wu, DM; Zhao, J; Zhai, QW |
| 刊名 | NEUROCHEMISTRY INTERNATIONAL
 |
| 出版日期 | 2010 |
| 卷号 | 56期号:1页码:101-106 |
| 关键词 | Wallerian degeneration Axonal protection Neurodegenerative disease NAD synthesis activity |
| 通讯作者 | Zhai, QW (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Nutr Sci, Key Lab Nutr & Metab, 294 Tai Yuan Rd, Shanghai 200031, Peoples R China.,qwzhai@sibs.ac.cn |
| 英文摘要 | Axon degeneration is an active program of self-destruction observed in many physiological and pathological settings. There are three Nicotinamide mononucleotide adenylyl transferase (Nmnat, EC2.7.7.1) in mammals. Overexpression of Nmnat1 or Nmnat3 can delay axon degeneration, while the role of Nmnat2 in axon degeneration remains largely unknown. Here we found that Nmnat2 was specifically and highly expressed in brain compared with Nmnat1 and Nmnat3. Furthermore, we found brain Nmnat2 was correlated with Alzheimer's disease in APPswe/PS1dE9 transgenic mice. Nmnat2 delayed Wallerian degeneration in cultured superior cervical ganglia (SCGs) from morphological changes, microtubule destruction and neurofilament degradation, mutation of the conserved enzyme activity site in Nmnat2 disrupted its enzyme activity as well as the axon-protective function. Our results demonstrate that the brain-specific Nmnat2 delays injury-induced axon degeneration dependent on its NAD synthesis activity. These findings provide new clues to further study the molecular mechanisms of axon degeneration and the related neurodegenerative diseases. (C) 2009 Elseviei Ltd. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology; Neurosciences & Neurology |
| 类目[WOS] | Biochemistry & Molecular Biology ; Neurosciences |
| 关键词[WOS] | NICOTINAMIDE MONONUCLEOTIDE ADENYLYLTRANSFERASE ; WALLERIAN DEGENERATION ; ADENINE-DINUCLEOTIDE ; ALZHEIMERS-DISEASE ; ENZYMATIC-ACTIVITY ; WLD(S) ; EXPRESSION ; PROTEIN ; NEURODEGENERATION ; IDENTIFICATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000275593700014 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/935]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Yan, TT,Feng, Y,Zheng, J,et al. Nmnat2 delays axon degeneration in superior cervical ganglia dependent on its NAD synthesis activity[J]. NEUROCHEMISTRY INTERNATIONAL,2010,56(1):101-106. |
| APA | Yan, TT.,Feng, Y.,Zheng, J.,Ge, XJ.,Zhang, Y.,...&Zhai, QW.(2010).Nmnat2 delays axon degeneration in superior cervical ganglia dependent on its NAD synthesis activity.NEUROCHEMISTRY INTERNATIONAL,56(1),101-106. |
| MLA | Yan, TT,et al."Nmnat2 delays axon degeneration in superior cervical ganglia dependent on its NAD synthesis activity".NEUROCHEMISTRY INTERNATIONAL 56.1(2010):101-106. |
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