Hsa-mir-182 suppresses lung tumorigenesis through down regulation of RGS17 expression in vitro
文献类型：期刊论文
| 作者 | Sun, YH; Fang, R; Li, CG; Li, L; Li, F; Ye, XL; Chen, HQ |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2010 |
| 卷号 | 396期号:2页码:501-507 |
| 关键词 | Lung cancer RGS17 Hsa-mir-182 |
| 通讯作者 | Chen, HQ (reprint author), Fudan Univ, Shanghai Canc Hosp, 270 Dong An Rd, Shanghai 200032, Peoples R China.,hqchen1@yahoo.com |
| 英文摘要 | Lung cancer is one of the most devastating diseases worldwide. RGS17 is previously shown to be overexpressed in human lung adenocarcinomas and plays an important role in lung tumor growth. Here we have identified a miRNA, has-mir-182, involved in the regulation of RGS17 expression through two conserved sites located in its 3' UTR region. Consistently, endogenous RGS17 expression level is regulated by hsa-mir-182 in human lung cancer cell lines. Similar to the knockdown of RGS17, ectopic expression of hsa-mir-182 significantly inhibits lung cancer cell proliferation and anchorage-independent cell growth, which can be rescued by re-expression of RGS17. Taken together, these data have provided the first evidence of miRNA regulation of RGS17 expression in lung cancer. (C) 2010 Elsevier Inc. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | CANCER ; MELANOMA ; SURVIVAL ; GENE ; ADENOCARCINOMA ; PROFILES ; CELLS ; RGS17/RGSZ2 ; MICRORNAS ; SIGNATURE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000278658000056 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/946]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Sun, YH,Fang, R,Li, CG,et al. Hsa-mir-182 suppresses lung tumorigenesis through down regulation of RGS17 expression in vitro[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2010,396(2):501-507. |
| APA | Sun, YH.,Fang, R.,Li, CG.,Li, L.,Li, F.,...&Chen, HQ.(2010).Hsa-mir-182 suppresses lung tumorigenesis through down regulation of RGS17 expression in vitro.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,396(2),501-507. |
| MLA | Sun, YH,et al."Hsa-mir-182 suppresses lung tumorigenesis through down regulation of RGS17 expression in vitro".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 396.2(2010):501-507. |
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