Slit-Robo signaling mediates lymphangiogenesis and promotes tumor lymphatic metastasis
文献类型：期刊论文
| 作者 | Yang, XM; Han, HX; Sui, F; Dai, YM; Chen, M; Geng, JG |
| 刊名 | BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
 |
| 出版日期 | 2010 |
| 卷号 | 396期号:2页码:571-577 |
| 关键词 | Slit Robo Lymphangiogenesis Tumor metastasis beta-Cell carcinoma |
| 通讯作者 | Geng, JG (reprint author), Univ Minnesota, Sch Med, Dept Med, Vasc Biol Ctr,Div Hematol Oncol & Transplantat, MMC 480,420 Delaware St SE, Minneapolis, MN 55455 USA.,genglab@gmail.com |
| 英文摘要 | The Slit family of guidance cues binds to Roundabout (Robo) receptors to modulate neuronal, leukocytic, and endothelial migration. Slit-Robo signaling had been reported to function as chemoattractive signal for vascular endothelial cells during angiogenesis. In this study, we found that Robo1 was expressed in lymphatic endothelial cells to mediate the migration and tube formation of these cells upon Slit2 stimulation, which were specifically inhibited by the function-blocking antibody R5 to Slit2/Robo1 interaction. To further explore the lymphangiogenic effect and significance mediated by Slit-Robo signaling, we intercrossed Slit2 transgenic mice with a non-metastatic RIP1-Tag2 mouse tumor model, and found that transgenic overexpression of Slit2 significantly enhanced tumor lymphangiogenesis and subsequently promoted mesenteric lymph node metastasis of pancreatic islet tumors. Taken together, our findings reveal that through interacting with Robo1, Slit2 is a novel and potent lymphangiogenic factor and contributes to tumor lymphatic metastasis. (C) 2010 Elsevier Inc. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | IN-VIVO ; GROWTH ; ANGIOGENESIS ; CELLS ; MECHANISMS ; GUIDANCE ; MODELS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000278658000068 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/947]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Yang, XM,Han, HX,Sui, F,et al. Slit-Robo signaling mediates lymphangiogenesis and promotes tumor lymphatic metastasis[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2010,396(2):571-577. |
| APA | Yang, XM,Han, HX,Sui, F,Dai, YM,Chen, M,&Geng, JG.(2010).Slit-Robo signaling mediates lymphangiogenesis and promotes tumor lymphatic metastasis.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,396(2),571-577. |
| MLA | Yang, XM,et al."Slit-Robo signaling mediates lymphangiogenesis and promotes tumor lymphatic metastasis".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 396.2(2010):571-577. |
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