Loss of beta arrestin1 and beta arrestin2 contributes to pulmonary hypoplasia and neonatal lethality in mice
文献类型：期刊论文
| 作者 | Zhang, MF; Liu, XS; Zhang, YD; Zhao, J |
| 刊名 | DEVELOPMENTAL BIOLOGY
 |
| 出版日期 | 2010 |
| 卷号 | 339期号:2页码:407-417 |
| 关键词 | beta arrestin Neonatal lethality Pulmonary hypoplasia Lung maturation |
| 通讯作者 | Zhao, J (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,jzhao@sibs.ac.cn |
| 英文摘要 | Less is known about the connection between the malfunction of beta arrestins and developmental defects as the mice with either of two beta arrestin isoforms knockout appear normal. In order to address the biological function of beta arrestins during developmental process, we generate beta arrestin1/2 double knockout mice. We found that beta arrestin1/2 dual-null mice developed respiratory distress and atelectasis that subsequently caused neonatal death. Morphological examination revealed type II pneumocyte immaturity. Our results indicate that not only beta arrestin1/2 double knockout lung tissue show disturbances in cell proliferation but beta arrestin1 and beta arrestin2 contribute to pulmonary surfactant complex generation during pulmonary maturation. Intra-amniotic delivery of recombinant adenovirus expressing beta arrestin1 or beta arrestin2 enhances surfactant-associated proteins synthesis in vivo. Our mRNA microarray data further reveal that beta arrestin1/2 double knockout results in clownregulation of a significant proportion of genes involved in several lung morphogenesis processes. Together, our study demonstrates that beta arrestin1 and beta arrestin2 collaborate in embryonic development processes for epithelial pneumocyte differentiation and lung maturation. (C) 2010 Elsevier Inc. All rights reserved. |
| 学科主题 | Developmental Biology |
| 类目[WOS] | Developmental Biology |
| 关键词[WOS] | FETAL LUNG DEVELOPMENT ; BETA-ARRESTIN ; CRYSTAL-STRUCTURE ; RAT LUNG ; PROTEIN ; CELL ; MORPHOGENESIS ; SURFACTANT ; EXPRESSION ; GROWTH |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000275174900019 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/951]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, MF,Liu, XS,Zhang, YD,et al. Loss of beta arrestin1 and beta arrestin2 contributes to pulmonary hypoplasia and neonatal lethality in mice[J]. DEVELOPMENTAL BIOLOGY,2010,339(2):407-417. |
| APA | Zhang, MF,Liu, XS,Zhang, YD,&Zhao, J.(2010).Loss of beta arrestin1 and beta arrestin2 contributes to pulmonary hypoplasia and neonatal lethality in mice.DEVELOPMENTAL BIOLOGY,339(2),407-417. |
| MLA | Zhang, MF,et al."Loss of beta arrestin1 and beta arrestin2 contributes to pulmonary hypoplasia and neonatal lethality in mice".DEVELOPMENTAL BIOLOGY 339.2(2010):407-417. |
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