Comparative profiling of genes and miRNAs expressed in the newborn, young adult, and aged human epididymides
文献类型：期刊论文
| 作者 | Zhang, JS; Liu, Q; Zhang, W; Li, JY; Li, Z; Tang, ZY; Li, YX; Han, CS; Hall, SH; Zhang, YL |
| 刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
 |
| 出版日期 | 2010 |
| 卷号 | 42期号:2页码:145-153 |
| 关键词 | epididymis microarray miRNA transcriptome transcriptional factor |
| 通讯作者 | Zhang, YL (reprint author), Chinese Acad Sci, Shanghai Key Lab Mol Androl, Inst Biochem & Cell Biol, State Key Lab Mol Biol,Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China.,ylzhang@sibs.ac.cn |
| 英文摘要 | To understand roles of transcriptional factors and miRNAs in regulating gene expression in the epididymis from postnatal development through aging, systematic profiling of genes and miRNAs expressed in the newborn, young adult, and aged human epididymides was performed by cDNA array and miRNA array analysis, respectively. The newborn human epididymis expressed the fewest mRNAs but the largest number of miRNAs, whereas the adult and aged epididymides expressed the most mRNAs but the fewest miRNAs, a negative correlation between mRNAs and miRNA during aging. By integrative analysis, a set of miRNA targets were predicted based on the miRNA and cDNA arrays. In the newborn epididymis, 127 miRNAs were exclusively or preferentially expressed but only 3 and 2 miRNAs showed an age-enriched expression pattern in the adult and aged epididymides, respectively. This study provides a basic database as well as new insights and foundations for further studies on the complex regulation of gene expression in the epididymis. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | BROWN-NORWAY RAT ; MESSENGER-RNA ; SPERMATOZOAL CHROMATIN ; OXIDATIVE CHALLENGE ; TESTICULAR FACTORS ; LEYDIG-CELLS ; IN-VIVO ; SEGMENT ; MICRORNAS ; DEHYDROGENASE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000274086700008 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/954]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, JS,Liu, Q,Zhang, W,et al. Comparative profiling of genes and miRNAs expressed in the newborn, young adult, and aged human epididymides[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2010,42(2):145-153. |
| APA | Zhang, JS.,Liu, Q.,Zhang, W.,Li, JY.,Li, Z.,...&Zhang, YL.(2010).Comparative profiling of genes and miRNAs expressed in the newborn, young adult, and aged human epididymides.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,42(2),145-153. |
| MLA | Zhang, JS,et al."Comparative profiling of genes and miRNAs expressed in the newborn, young adult, and aged human epididymides".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 42.2(2010):145-153. |
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