Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4
文献类型：期刊论文
| 作者 | Huang, CY; Xiang, Y; Wang, YR; Li, X; Xu, LY; Zhu, ZQ; Zhang, T; Zhu, QQ; Zhang, KJ; Jing, NH |
| 刊名 | CELL RESEARCH
 |
| 出版日期 | 2010 |
| 卷号 | 20期号:2页码:154-165 |
| 关键词 | histone demethylase KIAA1718 KDM7A neural differentiation FGF4 |
| 通讯作者 | Chen, CD (reprint author), Chinese Acad Sci, State Key Lab Mol Biol, Shanghai Key Lab Mol Androl, Shanghai Inst Biol Sci,Inst Biochem & Cell Biol, 320 Yueyang Rd, Shanghai 200031, Peoples R China.,njing@sibs.ac.cn ; cdchen@sibs.ac.cn |
| 英文摘要 | Dimethylations of histone H3 lysine 9 and lysine 27 are important epigenetic marks associated with transcription repression. Here, we identified KIAA1718 ( KDM7A) as a novel histone demethylase specific for these two repressing marks. Using mouse embryonic stem cells, we demonstrated that KIAA1718 expression increased at the early phase of neural differentiation. Knockdown of the gene blocked neural differentiation and the effect was rescued by the wild-type human gene, and not by a catalytically inactive mutant. In addition, overexpression of KIAA1718 accelerated neural differentiation. We provide the evidence that the pro-neural differentiation effect of KDM7A is mediated through direct transcriptional activation of FGF4, a signal molecule implicated in neural differentiation. Thus, our study identified a dual-specificity histone demethylase that regulates neural differentiation through FGF4. |
| 学科主题 | Cell Biology |
| 类目[WOS] | Cell Biology |
| 关键词[WOS] | EMBRYONIC STEM-CELLS ; DOMAIN-CONTAINING PROTEINS ; TRANSCRIPTIONAL REPRESSION ; METHYLTRANSFERASE ACTIVITY ; COVALENT MODIFICATIONS ; MOUSE DEVELOPMENT ; JMJD2 FAMILY ; METHYLATION ; H3 ; CHROMATIN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000275816100007 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/957]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Huang, CY,Xiang, Y,Wang, YR,et al. Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4[J]. CELL RESEARCH,2010,20(2):154-165. |
| APA | Huang, CY.,Xiang, Y.,Wang, YR.,Li, X.,Xu, LY.,...&Chen, CD.(2010).Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4.CELL RESEARCH,20(2),154-165. |
| MLA | Huang, CY,et al."Dual-specificity histone demethylase KIAA1718 (KDM7A) regulates neural differentiation through FGF4".CELL RESEARCH 20.2(2010):154-165. |
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