Hippo signaling regulates Yorkie nuclear localization and activity through 14-3-3 dependent and independent mechanisms
文献类型：期刊论文
| 作者 | Ren, FF; Zhang, L; Jiang, J |
| 刊名 | DEVELOPMENTAL BIOLOGY
 |
| 出版日期 | 2010 |
| 卷号 | 337期号:2页码:303-312 |
| 关键词 | Cell growth Organ size Tumor suppressor Hpo Yki Yap 14-3-3 Nuclear export Phosphorylation Kinase |
| 通讯作者 | Jiang, J (reprint author), Univ Texas SW Med Ctr Dallas, Dept Dev Biol, Dallas, TX 75390 USA.,jin.jiang@utsouthwestern.edu |
| 英文摘要 | The Hippo (Hpo) signaling pathway controls cell growth, proliferation and apoptosis in both Drosophila and vertebrates. In Drosophila, Hpo signaling regulates gene expression by inhibiting a transcription complex consisting of the transcriptional coactivator Yorkie (Yki) and the TEAD/TEF family of transcription factor Scalloped (Sd). Here we provide genetic evidence that both isoforms of 14-3-3, 14-3-3 epsilon and 14-3-3 zeta, regulate Yki activity through modulating its subcellular localization. Inactivation of 14-3-3 by RNAi or genetic mutations enhanced whereas overexpression of 14-3-3 suppressed tissue overgrowth induced by Yki overexpression. Loss of 14-3-3 resulted in the accumulation of Yki in the nucleus. We found that regulation of Yki by 14-3-3 was mediated by phosphorylation of Yki at S168. In addition, we found that Hpo signaling also inhibited Yki nuclear localization and activity by phosphorylating Yki at S111 and S250, and this inhibition appears to be independent of 14-3-3. Finally, we provided evidence that Hpo signaling restricted Yki nuclear localization depending on CRM1-mediated nuclear export. (C) 2009 Elsevier Inc. All rights reserved. |
| 学科主题 | Developmental Biology |
| 类目[WOS] | Developmental Biology |
| 关键词[WOS] | TUMOR-SUPPRESSOR PATHWAY ; ORGAN SIZE CONTROL ; PROTEIN-KINASE-A ; CELL-CYCLE EXIT ; PROMOTES APOPTOSIS ; TEAD/TEF FAMILY ; DROSOPHILA ; PROLIFERATION ; GROWTH ; GENE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000273948300011 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/964]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Ren, FF,Zhang, L,Jiang, J. Hippo signaling regulates Yorkie nuclear localization and activity through 14-3-3 dependent and independent mechanisms[J]. DEVELOPMENTAL BIOLOGY,2010,337(2):303-312. |
| APA | Ren, FF,Zhang, L,&Jiang, J.(2010).Hippo signaling regulates Yorkie nuclear localization and activity through 14-3-3 dependent and independent mechanisms.DEVELOPMENTAL BIOLOGY,337(2),303-312. |
| MLA | Ren, FF,et al."Hippo signaling regulates Yorkie nuclear localization and activity through 14-3-3 dependent and independent mechanisms".DEVELOPMENTAL BIOLOGY 337.2(2010):303-312. |
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