Targeting Gene-ViroTherapy for prostate cancer by DD3-driven oncolytic virus-harboring interleukin-24 gene
文献类型：期刊论文
| 作者 | Fan, JK; Wei, N; Ding, MA; Gu, JF; Liu, XR; Li, BH; Qi, R; Huang, WD; Li, YH; Xiong, XQ |
| 刊名 | INTERNATIONAL JOURNAL OF CANCER
 |
| 出版日期 | 2010 |
| 卷号 | 127期号:3页码:707-717 |
| 关键词 | DD3 IL-24 oncolytic adenovirus apoptosis prostate cancer |
| 通讯作者 | Liu, XY (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, Shanghai 200031, Peoples R China.,runshengli2007@gmail.com ; xyliu@sibs.ac.cn |
| 英文摘要 | Prostate cancer (PCa) is the second leading cause of cancer-related deaths in Western male population. Previous studies have demonstrated that differential display code 3 (DD3 or DD3(PCA3)) is one of the most PCa-specific genes; therefore, it has been used as a clinical diagnostic marker for PCa. In this study, we constructed an oncolytic adenovirus Ad.DD3-E1A by using the minimal DD3 promoter to replace the native viral promoter of E1A gene. In addition, Ad.DD3-E1A was armed with therapeutic gene IL-24 to enhance its antitumor activity. The resulting adenovirus, Ad.DD3-E1A-IL-24, demonstrated PCa specificity and excellent antitumor effect. Further analyses on its antitumor mechanism revealed that it has the capacity to induce apoptosis in PCa cells and inhibit angiogenesis. These results suggest that Ad.DD3-E1A-IL-24 is a promising antitumor agent that may be able to be used in the future as a treatment for PCa. |
| 学科主题 | Oncology |
| 类目[WOS] | Oncology |
| 关键词[WOS] | DIFFERENTIATION-ASSOCIATED GENE-7 ; MELANOMA-DIFFERENTIATION ; REPLICATING ADENOVIRUS ; TUMOR-CELLS ; MDA-7/IL-24 ; THERAPY ; GROWTH ; CARCINOMA ; MDA-7 ; EXPRESSION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000279131300022 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/969]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Fan, JK,Wei, N,Ding, MA,et al. Targeting Gene-ViroTherapy for prostate cancer by DD3-driven oncolytic virus-harboring interleukin-24 gene[J]. INTERNATIONAL JOURNAL OF CANCER,2010,127(3):707-717. |
| APA | Fan, JK.,Wei, N.,Ding, MA.,Gu, JF.,Liu, XR.,...&Liu, XY.(2010).Targeting Gene-ViroTherapy for prostate cancer by DD3-driven oncolytic virus-harboring interleukin-24 gene.INTERNATIONAL JOURNAL OF CANCER,127(3),707-717. |
| MLA | Fan, JK,et al."Targeting Gene-ViroTherapy for prostate cancer by DD3-driven oncolytic virus-harboring interleukin-24 gene".INTERNATIONAL JOURNAL OF CANCER 127.3(2010):707-717. |
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