ASK1-JNK Signaling Cascade Mediated Ad-ST13-Induced Apoptosis in Colorectal HCT116 Cells
文献类型：期刊论文
| 作者 | Yang, M; Yu, M; Guan, DG; Gli, J; Cao, X; Wang, WY; Zheng, S; Xu, YY; Shen, ZH; Liu, XY |
| 刊名 | JOURNAL OF CELLULAR BIOCHEMISTRY
 |
| 出版日期 | 2010 |
| 卷号 | 110期号:3页码:581-588 |
| 关键词 | ST13 HIP ASK1 JNK APOPTOSIS |
| 通讯作者 | Shen, ZH (reprint author), Fudan Univ, Shanghai Med Coll, Dept Biochem & Mol Biol, Shanghai 200032, Peoples R China.,zhshen@shmu.edu.cn |
| 英文摘要 | ST13, a co-factor of heat shock protein, has shown potential antitumor efficacy for colorectal cancer in our previous study. However, the molecular mechanisms governing ST13-induced apoptosis are poorly understood. Here, we demonstrate that Ad-ST13 (ST13 mediated by adenovirus) activates apoptosis signal-regulated kinase (ASK I) and c-Jun N-terminal kinase (JNK) but not p38 (mitogen-activated protein kinase) in human colorectal HCT116 cells. Ad-ST13 also increases extracellular-regulated kinase (ERK) phosphorylation levels, but the change is due to adenovirus replication. Overexpression of ST13 also increases the transcription activity of AP-1. Blocking ASK1-JNK pathway affects Ad-ST13-mediated colorectal cell apoptosis, decreases the release of cytochrome c in cytoplasm and caspase activation. Because ASK! is known to contain a tetratricopeptide repeat (TPR)-acceptor site and ST13 has TPR domain, we found the interaction between ST13 and ASK1. These results strongly indicate Ad-ST13 triggers colorectal cell apoptosis via ASK1-JNK signaling cascade. J. Cell. Biochem. 110: 581-588, 2010. (C) 2010 Wiley-Liss, Inc. |
| 学科主题 | Biochemistry & Molecular Biology; Cell Biology |
| 类目[WOS] | Biochemistry & Molecular Biology ; Cell Biology |
| 关键词[WOS] | HEAT-SHOCK-PROTEIN ; N-TERMINAL KINASE ; ONCOLYTIC ADENOVIRUS ; TRANSDUCTION PATHWAY ; REGULATING KINASE-1 ; TUMOR-SUPPRESSOR ; CYTOCHROME-C ; ACTIVATION ; DEATH ; ST13 |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000278837200005 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/970]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Yang, M,Yu, M,Guan, DG,et al. ASK1-JNK Signaling Cascade Mediated Ad-ST13-Induced Apoptosis in Colorectal HCT116 Cells[J]. JOURNAL OF CELLULAR BIOCHEMISTRY,2010,110(3):581-588. |
| APA | Yang, M.,Yu, M.,Guan, DG.,Gli, J.,Cao, X.,...&Liu, XY.(2010).ASK1-JNK Signaling Cascade Mediated Ad-ST13-Induced Apoptosis in Colorectal HCT116 Cells.JOURNAL OF CELLULAR BIOCHEMISTRY,110(3),581-588. |
| MLA | Yang, M,et al."ASK1-JNK Signaling Cascade Mediated Ad-ST13-Induced Apoptosis in Colorectal HCT116 Cells".JOURNAL OF CELLULAR BIOCHEMISTRY 110.3(2010):581-588. |
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