microRNAs: critical regulators in Th17 cells and players in diseases
文献类型：期刊论文
| 作者 | Wei, B; Pei, G |
| 刊名 | CELLULAR & MOLECULAR IMMUNOLOGY
 |
| 出版日期 | 2010 |
| 卷号 | 7期号:3页码:175-181 |
| 关键词 | autoimmune diseases microRNAs Th17 cells |
| 通讯作者 | Wei, B (reprint author), Chinese Acad Sci, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Mol Cell Biol Lab, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,weibin@sibs.ac.cn |
| 英文摘要 | microRNAs are a novel group of small, conserved, non-coding RNA molecules that are present in all species. These molecules post-transcriptionally regulate gene expression by targeting mRNAs for degradation or by repressing the translation of the mRNAs. A good understanding of miRNA-mediated gene regulation is critical to gain a comprehensive view of many physiological processes and disease states. Emerging evidence demonstrates that miRNAs play an important role in the differentiation and function of the adaptive immune system. This review provides an overview of the diverse functions of miRNAs in modulating immune responses and in immune cell development, particularly the development of Th17 cells, and explores the involvement of miRNAs in several autoimmune diseases including multiple sclerosis ( MS), rheumatoid arthritis ( RA), inflammatory bowel disease (IBD) and diabetes. Cellular & Molecular Immunology (2010) 7, 175-181; doi:10.1038/cmi.2010.19; published online 5 April 2010 |
| 学科主题 | Immunology |
| 类目[WOS] | Immunology |
| 关键词[WOS] | MULTIPLE-SCLEROSIS ; T-CELLS ; DIFFERENTIATION ; EXPRESSION ; GENES ; DICER ; LINEAGE ; TARGETS ; RNAS ; AUTOIMMUNITY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000277282200003 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/972]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Wei, B,Pei, G. microRNAs: critical regulators in Th17 cells and players in diseases[J]. CELLULAR & MOLECULAR IMMUNOLOGY,2010,7(3):175-181. |
| APA | Wei, B,&Pei, G.(2010).microRNAs: critical regulators in Th17 cells and players in diseases.CELLULAR & MOLECULAR IMMUNOLOGY,7(3),175-181. |
| MLA | Wei, B,et al."microRNAs: critical regulators in Th17 cells and players in diseases".CELLULAR & MOLECULAR IMMUNOLOGY 7.3(2010):175-181. |
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