Involvement of CENP-F in histone methylation
文献类型：期刊论文
| 作者 | Du, J; Li, Y; Zhu, XL |
| 刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
 |
| 出版日期 | 2010 |
| 卷号 | 42期号:3页码:173-176 |
| 关键词 | CENP-F mitosin histone methylation HP1 |
| 通讯作者 | Zhu, XL (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, Shanghai 200031, Peoples R China.,xlzhu@sibs.ac.cn |
| 英文摘要 | CENP-F (also named mitosin) is a multifunctional protein of 350 kDa. In interphase, it is a nuclear protein, whereas in M phase it localizes to the kinetochore, the major microtubule-binding structure on chromosomes essential for chromosome segregation. CENP-F is also critical for myocyte differentiation through the interaction with Rb. It binds to ATF4 and negatively regulates the transcriptional activity of ATF4. It is also important for mitotic progression. Here we show that depletion of CENP-F by RNAi markedly downregulated the methylation of histone H3 at K4 and K9. Consistently, association of HP1 alpha with mitotic chromosomes was largely decreased. These results uncover a novel role of CENP-F in regulation of epigenetic modification on histone H3. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | MITOSIN/CENP-F ; CYTOPLASMIC DYNEIN ; LYSINE METHYLATION ; CELL-CYCLE ; PROTEIN ; LOCALIZATION ; HP1 ; PHOSPHORYLATION ; DIFFERENTIATION ; KINETOCHORES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000274780600001 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/975]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Du, J,Li, Y,Zhu, XL. Involvement of CENP-F in histone methylation[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2010,42(3):173-176. |
| APA | Du, J,Li, Y,&Zhu, XL.(2010).Involvement of CENP-F in histone methylation.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,42(3),173-176. |
| MLA | Du, J,et al."Involvement of CENP-F in histone methylation".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 42.3(2010):173-176. |
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