VEGI-armed oncolytic adenovirus inhibits tumor neovascularization and directly induces mitochondria-mediated cancer cell apoptosis
文献类型：期刊论文
| 作者 | Xiao, T; Fan, JK; Huang, HL; Gu, JF; Li, LY; Liu, XY |
| 刊名 | CELL RESEARCH
 |
| 出版日期 | 2010 |
| 卷号 | 20期号:3页码:367-378 |
| 关键词 | VEGI-251 oncolytic adenovirus antiangiogenesis apoptosis tumor therapy |
| 通讯作者 | Liu, XY (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, Shanghai 200031, Peoples R China.,lil@upmc.edu ; xyliu@sibs.ac.cn |
| 英文摘要 | Vascular endothelial cell growth inhibitor (VEGI) is a member of the tumor necrosis factor superfamily and plays an important role in vascular homeostasis. In this study, to investigate the anticancer therapeutic potential of this gene, a secreted isoform of VEGI (VEGI-251) was inserted into a selectively replicating adenovirus with E1B 55 kDa gene deletion (ZD55) to construct ZD55-VEGI-251. We report here that secreted VEGI-251 produced from ZD55-VEGI-251-infected cancer cells potently inhibits endothelial cell proliferation, tube formation in vitro and angiogenesis of chick chorioallantoic membrane in vivo. Additionally, ZD55-VEGI-251 infection leads to a much more severe cytopathic effect than control viruses on several human cancer cell lines, including cervical cancer cell line HeLa, hepatoma cell line SMMC-7721 and colorectal cancer cell line SW620. Further study reveals that the increased cytotoxicity is a result of VEGI-251 autocrine-dependent, mitochondria-mediated apoptosis accompanied by caspase-9 activation, enhanced caspase-3 activation and PARP cleavage. Moreover, ZD55-VEGI-251-treatment of athymic nude mice bearing human cervical and colorectal tumor xenografts markedly suppressed tumor growth. Our findings indicate that the combined effect of antiangiogenesis and apoptosis-induction activity makes the VEGI-251-armed oncolytic adenovirus a promising therapeutic agent for cancer. |
| 学科主题 | Cell Biology |
| 类目[WOS] | Cell Biology |
| 关键词[WOS] | ENDOTHELIAL GROWTH INHIBITOR ; GENE-VIROTHERAPY ; T-CELL ; ANGIOGENESIS ; CYTOKINE ; TL1A ; COSTIMULATOR ; SUPERFAMILY ; CASPASE-8 ; XENOGRAFT |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000275816300012 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/976]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Xiao, T,Fan, JK,Huang, HL,et al. VEGI-armed oncolytic adenovirus inhibits tumor neovascularization and directly induces mitochondria-mediated cancer cell apoptosis[J]. CELL RESEARCH,2010,20(3):367-378. |
| APA | Xiao, T,Fan, JK,Huang, HL,Gu, JF,Li, LY,&Liu, XY.(2010).VEGI-armed oncolytic adenovirus inhibits tumor neovascularization and directly induces mitochondria-mediated cancer cell apoptosis.CELL RESEARCH,20(3),367-378. |
| MLA | Xiao, T,et al."VEGI-armed oncolytic adenovirus inhibits tumor neovascularization and directly induces mitochondria-mediated cancer cell apoptosis".CELL RESEARCH 20.3(2010):367-378. |
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