Total glucosides of Paeonia lactiflora Pall inhibit vascular endothelial growth factor-induced angiogenesis
文献类型：期刊论文
| 作者 | Deng, H; Yan, CL; Xiao, J; Yuan, DF; Xu, JH |
| 刊名 | JOURNAL OF ETHNOPHARMACOLOGY
 |
| 出版日期 | 2010 |
| 卷号 | 127期号:3页码:781-785 |
| 关键词 | Total glucosides of Paeonia lactiflora Pall Angiogenesis Endothelial cell |
| 通讯作者 | Xu, JH (reprint author), Fudan Univ, Huashan Hosp, Dept Dermatol, Wulumuqi Middle Rd 12, Shanghai 200233, Peoples R China.,Jinhua_xu@live.cn |
| 英文摘要 | Objective: To evaluate the anti-angiogenesis effect of total glucosides of Paeonia lactiflora Pall. Methods: In this study, we determined the effect of TGP on the proliferation of human vascular endothelial cells through 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and fluorescence-activated cell sorting analysis. A migration assay and a tube formation assay were used to investigate the migration properties and tube formation abilities of human vascular endothelial cells after being treated with TGP. Furthermore, the in vivo anti-angiogenic ability of TGP was determined through a chick chorioallantoic membrane assay. Results: TGP (12.5, 62.5, and 312.5 mu g/ml) resulted in a dose-dependent reduction in the proliferation of endothelial cells. This inhibition effect began 6 h after treatment and lasted at least 24 h. Fluorescence-activated cell sorting analysis data showed an accumulation of cells in the G0/G1 phase of the cell cycle, which exhibited apoptotic features indicative of cell death. The migration properties and tube forming abilities of endothelial cells were dramatically inhibited by the TGP extract. Conclusion: Our results show that TGP can inhibit angiogenesis in vitro and in vivo. (C) 2009 Elsevier Ireland Ltd. All rights reserved. |
| 学科主题 | Plant Sciences ; Pharmacology & Pharmacy ; Integrative & Complementary Medicine |
| 类目[WOS] | Plant Sciences ; Chemistry, Medicinal ; Integrative & Complementary Medicine ; Pharmacology & Pharmacy |
| 关键词[WOS] | ADJUVANT ARTHRITIS ; PEONY ; MECHANISMS ; RATS ; PAEONIFLORIN ; DISEASE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000275628600031 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/982]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Deng, H,Yan, CL,Xiao, J,et al. Total glucosides of Paeonia lactiflora Pall inhibit vascular endothelial growth factor-induced angiogenesis[J]. JOURNAL OF ETHNOPHARMACOLOGY,2010,127(3):781-785. |
| APA | Deng, H,Yan, CL,Xiao, J,Yuan, DF,&Xu, JH.(2010).Total glucosides of Paeonia lactiflora Pall inhibit vascular endothelial growth factor-induced angiogenesis.JOURNAL OF ETHNOPHARMACOLOGY,127(3),781-785. |
| MLA | Deng, H,et al."Total glucosides of Paeonia lactiflora Pall inhibit vascular endothelial growth factor-induced angiogenesis".JOURNAL OF ETHNOPHARMACOLOGY 127.3(2010):781-785. |
入库方式： OAI收割
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。