Entry of hepatitis B virus: Mechanism and new therapeutic target
文献类型：期刊论文
| 作者 | Xie, Y; Zhai, J; Deng, Q; Tiollais, P; Wang, Y; Zhao, M |
| 刊名 | PATHOLOGIE BIOLOGIE
 |
| 出版日期 | 2010 |
| 卷号 | 58期号:4页码:301-307 |
| 关键词 | Hepatitis B virus Entry PreS1 Peptide Primary hepatocyte |
| 通讯作者 | Xie, Y (reprint author), 138 Yixueyuan Rd, Shanghai 200032, Peoples R China., |
| 英文摘要 | Entry of hepatitis B virus (HBV) into human hepatocytes constitutes the initial step in viral infection. The study of HBV entry had long been hampered by the lack of efficient cell culture systems and small animal models The situation was greatly improved in the last decade with the development of HBV-infectible HepaRG cell line and primary Tupaia hepatocyte culture. Armed with these new tools, marked progresses have been achieved in the elucidation of the mechanism of HBV entry Plenty of evidences indicate that the viral large surface protein (LHBs) is essential for HBV entry. Several regions in the PreS1 domain of LHBs have been verified to contribute directly to the viral attachment In addition, a myristate moiety linked to the N-terminal glycine of PreS1 appears critical for HBV infectivity. Recently, the cysteine-rich antigenic loop of the S domain was identified as another crucial determinant for HBV infectivity On the other hand, several cellular proteins were implicated in HBV attachment to hepatic cells, though definitive proofs are required in support to their functional involvement in HBV infection. Aiming to blocking viral entry, a couple of approaches based on acylated PreS1-derived peptides and short PreS1-binding peptides are currently under investigation, which have the potential to become novel antiviral therapeutics (C) 2010 Elsevier Masson SAS. All rights reserved. |
| 学科主题 | Pathology |
| 类目[WOS] | Pathology |
| 关键词[WOS] | LARGE ENVELOPE PROTEIN ; RECEPTOR-BINDING SITE ; LARGE SURFACE PROTEIN ; HEPATOMA-CELL LINE ; ADULT HUMAN HEPATOCYTES ; LIVER REPOPULATION ; TUPAIA HEPATOCYTES ; HEPATOCELLULAR-CARCINOMA ; TRANSMEMBRANE TOPOLOGY ; DELTA-VIRUS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000281052500010 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/990]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Xie, Y,Zhai, J,Deng, Q,et al. Entry of hepatitis B virus: Mechanism and new therapeutic target[J]. PATHOLOGIE BIOLOGIE,2010,58(4):301-307. |
| APA | Xie, Y,Zhai, J,Deng, Q,Tiollais, P,Wang, Y,&Zhao, M.(2010).Entry of hepatitis B virus: Mechanism and new therapeutic target.PATHOLOGIE BIOLOGIE,58(4),301-307. |
| MLA | Xie, Y,et al."Entry of hepatitis B virus: Mechanism and new therapeutic target".PATHOLOGIE BIOLOGIE 58.4(2010):301-307. |
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