Solution structure of the N-terminal domain of DC-UbP/UBTD2 and its interaction with ubiquitin
文献类型：期刊论文
| 作者 | Song, AX; Zhou, CJ; Guan, X; Sze, KH; Hu, HY |
| 刊名 | PROTEIN SCIENCE
 |
| 出版日期 | 2010 |
| 卷号 | 19期号:5页码:1104-1109 |
| 关键词 | DC-UbP/UBTD2 solution structure ubiquitin-binding domain ubiquitin-like domain NMR |
| 通讯作者 | Hu, HY (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, Shanghai 200031, Peoples R China.,hyhu@sibs.ac.cn |
| 英文摘要 | DC-UbP/UBTD2 is a ubiquitin (Ub) domain-containing protein first identified from dendritic cells, and is implicated in ubiquitination pathway. The solution structure and backbone dynamics of the C-terminal Ub-like (UbL) domain were elucidated in our previous work. To further understand the biological function of DC-UbP, we then solved the solution structure of the N-terminal domain of DC-UbP (DC-UbP_N) and studied its Ub binding properties by NMR techniques. The results show that DC-UbP_N holds a novel structural fold and acts as a Ub-binding domain (UBD) but with low affinity. This implies that the DC-UbP protein, composing of a combination of both UbL and UBD domains, might play an important role in regulating protein ubiquitination and delivery of ubiquitinated substrates in eukaryotic cells. |
| 学科主题 | Biochemistry & Molecular Biology |
| 类目[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | BINDING DOMAINS ; DENDRITIC CELLS ; CHEMICAL-SHIFT ; UBA DOMAINS ; SH3 DOMAINS ; DC-UBP ; PROTEIN ; NMR ; IDENTIFICATION ; RECOGNITION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000277279500019 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1007]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Song, AX,Zhou, CJ,Guan, X,et al. Solution structure of the N-terminal domain of DC-UbP/UBTD2 and its interaction with ubiquitin[J]. PROTEIN SCIENCE,2010,19(5):1104-1109. |
| APA | Song, AX,Zhou, CJ,Guan, X,Sze, KH,&Hu, HY.(2010).Solution structure of the N-terminal domain of DC-UbP/UBTD2 and its interaction with ubiquitin.PROTEIN SCIENCE,19(5),1104-1109. |
| MLA | Song, AX,et al."Solution structure of the N-terminal domain of DC-UbP/UBTD2 and its interaction with ubiquitin".PROTEIN SCIENCE 19.5(2010):1104-1109. |
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