Preparation of Uniform, Water-Soluble, and Multifunctional Nanocomposites with Tunable Sizes
文献类型：期刊论文
| 作者 | Niu, DC; Li, YS; Ma, Z; Diao, H; Gu, JL; Chen, HR; Zhao, WR; Ruan, ML; Zhang, YL; Shi, JL |
| 刊名 | ADVANCED FUNCTIONAL MATERIALS
 |
| 出版日期 | 2010 |
| 卷号 | 20期号:5页码:773-780 |
| 通讯作者 | Niu, DC (reprint author), E China Univ Sci & Technol, Sch Mat Sci & Engn, Minist Educ, Key Lab Ultrafine Mat, Shanghai 200237, Peoples R China.,ysli@ecust.edu.cn ; jlshi@sunm.shcnc.ac.cn |
| 英文摘要 | Novel, thiol-functionalized, and superparamagnetic, silica composite nanospheres (SH-SSCNs) with diameters smaller than 100 nm are successfully fabricated through the self-assembly of Fe(3)O(4) nanoparticles and polystyrene(100)-block-poly(acrylic acid)(16) and a subsequent sol-gel process The size and. magnetic properties of the SH-SSCNs can be easily tuned by simply varying the initial concentrations of the magnetite nanoparticles in the oil phase. By incorporating fluorescent dye molecules into the silica network the composite, nanospheres can be further fluorescent-functionalized. The toxicity of the SH-SSCNs is evaluated by choosing three typical cell lines (HUVEC RAW264.7 and A549) as model cells, and no toxic effects are observed. It is also demonstrated that SH-SSCNs can be used as a new class of magnetic resonance imaging (MRI) probes, having a remarkably high spin-spin (T(2)) relaxivity (r(2)* = 176.1 mm(-1) S(-1)). The combination of the sub-100-nm particle size monodispersity in aqueous solution, superparamagnetism and fluorescent properties of the SH-SSCNs, as well as the non-cytotoxicity in vitro, provides a novel and potential candidate for an earlier MRI diagnostic method of cancer. |
| 学科主题 | Chemistry; Science & Technology - Other Topics; Materials Science; Physics |
| 类目[WOS] | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| 关键词[WOS] | QUANTUM DOTS ; GOLD NANOPARTICLES ; ORGANOSILICA NANOPARTICLES ; CROSS-LINKING ; SILICA ; FUNCTIONALIZATION ; MONODISPERSE ; MICELLES ; ROBUST |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000275937000011 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1008]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Niu, DC,Li, YS,Ma, Z,et al. Preparation of Uniform, Water-Soluble, and Multifunctional Nanocomposites with Tunable Sizes[J]. ADVANCED FUNCTIONAL MATERIALS,2010,20(5):773-780. |
| APA | Niu, DC.,Li, YS.,Ma, Z.,Diao, H.,Gu, JL.,...&Shi, JL.(2010).Preparation of Uniform, Water-Soluble, and Multifunctional Nanocomposites with Tunable Sizes.ADVANCED FUNCTIONAL MATERIALS,20(5),773-780. |
| MLA | Niu, DC,et al."Preparation of Uniform, Water-Soluble, and Multifunctional Nanocomposites with Tunable Sizes".ADVANCED FUNCTIONAL MATERIALS 20.5(2010):773-780. |
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