Integrative Genomic and Proteomic Analyses Identify Targets for Lkb1-Deficient Metastatic Lung Tumors
文献类型：期刊论文
| 作者 | Carretero, J; Shimamura, T; Rikova, K; Jackson, AL; Wilkerson, MD; Borgman, CL; Buttarazzi, MS; Sanofsky, BA; McNamara, KL; Brandstetter, KA |
| 刊名 | CANCER CELL
 |
| 出版日期 | 2010 |
| 卷号 | 17期号:6页码:547-559 |
| 通讯作者 | Wong, KK (reprint author), Dana Farber Canc Inst, Dept Med Oncol, 44 Binney St, Boston, MA 02115 USA.,kwong1@partners.org |
| 英文摘要 | In mice, Lkb1 deletion and activation of KraS(G12D) results in lung tumors with a high penetrance of lymph node and distant metastases. We analyzed these primary and metastatic de novo lung cancers with integrated genomic and proteomic profiles, and have identified gene and phosphoprotein signatures associated with Lkb1 loss and progression to invasive and metastatic lung tumors. These studies revealed that SRC is activated in Lkb1-deficient primary and metastatic lung tumors, and that the combined inhibition of SRC, PI3K, and MEK1/2 resulted in synergistic tumor regression. These studies demonstrate that integrated genomic and proteomic analyses can be used to identify signaling pathways that may be targeted for treatment. |
| 学科主题 | Oncology ; Cell Biology |
| 类目[WOS] | Oncology ; Cell Biology |
| 关键词[WOS] | EPITHELIAL-MESENCHYMAL TRANSITION ; ONCOGENIC K-RAS ; KINASE INHIBITOR ; CANCER-CELLS ; EXPRESSION PROFILES ; GENE ; SRC ; TUMORIGENESIS ; SUPPRESSOR ; MUTATIONS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000278952300007 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1014]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Carretero, J,Shimamura, T,Rikova, K,et al. Integrative Genomic and Proteomic Analyses Identify Targets for Lkb1-Deficient Metastatic Lung Tumors[J]. CANCER CELL,2010,17(6):547-559. |
| APA | Carretero, J.,Shimamura, T.,Rikova, K.,Jackson, AL.,Wilkerson, MD.,...&Wong, KK.(2010).Integrative Genomic and Proteomic Analyses Identify Targets for Lkb1-Deficient Metastatic Lung Tumors.CANCER CELL,17(6),547-559. |
| MLA | Carretero, J,et al."Integrative Genomic and Proteomic Analyses Identify Targets for Lkb1-Deficient Metastatic Lung Tumors".CANCER CELL 17.6(2010):547-559. |
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