Novel conopeptides in a form of disulfide-crosslinked dimer
文献类型：期刊论文
| 作者 | Wu, XC; Zhou, M; Peng, C; Shao, XX; Guo, ZY; Chi, CW |
| 刊名 | PEPTIDES
 |
| 出版日期 | 2010 |
| 卷号 | 31期号:6页码:1001-1006 |
| 关键词 | Conopeptide Dimer Disulfide M-superfamily |
| 通讯作者 | Guo, ZY (reprint author), Tongji Univ, Inst Prot Res, 1239 Siping Rd, Shanghai 200092, Peoples R China.,zhan-yun.guo@tongji.edu.cn ; zwqi@sibs.ac.cn |
| 英文摘要 | In our present work, seven conotoxins and conopeptides were cloned from four cone snail species based on the M-superfamily signal peptides. Among them, two conopeptides, Vt3.1 and Vt3.2, showed unusual sequence characteristics. Both of them contained two cysteines that are separated by just one non-cysteine residue. In vitro, the chemically synthesized Vt3.1 formed dimers with different intermolecular disulfide linkages. Only the dimer with crossed disulfides showed bioactivity when injected into the intraventricular region of mice brains. Therefore, Vt3.1 and Vt3.2 represent a new group of conopeptides that form disulfide-crosslinked dimers in vitro and probably in vivo. (C) 2010 Elsevier Inc. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology; Pharmacology & Pharmacy |
| 类目[WOS] | Biochemistry & Molecular Biology ; Pharmacology & Pharmacy |
| 关键词[WOS] | M-SUPERFAMILY CONOTOXINS ; CDNA CLONING ; CONUS VENOMS ; PEPTIDES ; PRECURSORS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000283939000003 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1018]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Wu, XC,Zhou, M,Peng, C,et al. Novel conopeptides in a form of disulfide-crosslinked dimer[J]. PEPTIDES,2010,31(6):1001-1006. |
| APA | Wu, XC,Zhou, M,Peng, C,Shao, XX,Guo, ZY,&Chi, CW.(2010).Novel conopeptides in a form of disulfide-crosslinked dimer.PEPTIDES,31(6),1001-1006. |
| MLA | Wu, XC,et al."Novel conopeptides in a form of disulfide-crosslinked dimer".PEPTIDES 31.6(2010):1001-1006. |
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