Structural Identification of a New Tri-p-coumaroylspermidine with Serotonin Transporter Inhibition from Safflower
文献类型：期刊论文
| 作者 | Zhao, G; Qin, GW; Gai, Y; Guo, LH |
| 刊名 | CHEMICAL & PHARMACEUTICAL BULLETIN
 |
| 出版日期 | 2010 |
| 卷号 | 58期号:7页码:950-952 |
| 关键词 | Carthamus tinctorius tri-p-coumaroylspermidine transporter inhibitor |
| 通讯作者 | Zhao, G (reprint author), Cell Star Biotechnol Co Ltd, Bldg 6,Lane 898,Halei Rd, Shanghai 201203, Peoples R China.,zhaogangtcm@hotmail.com ; lhguo@sibs.ac.cn |
| 英文摘要 | We previously reported that safflower (Carthamus tinctorius L.) ethyl acetate extract (HE) possessed an inhibitory action on serotonin (5HT) uptake in Chinese hamster ovary (CHO) cells expressing 5HT transporter (SERT) (S6 cells). Here, HE was adopted to go through an activity-guided isolation, and then an ingredient with potent SERT inhibitory action was obtained, which was elucidated as N-1,N-5-(Z)-N-10-(E)-tri-p-coumaroylspermidine (CX), a new coumaroylspermidine analog, by using spectroscopic methods including extensive 1D- and 2D-NMR analyses. Preliminary pharmacological study demonstrated that CX was a potent SERT inhibitor. |
| 学科主题 | Pharmacology & Pharmacy; Chemistry |
| 类目[WOS] | Chemistry, Medicinal ; Chemistry, Multidisciplinary ; Pharmacology & Pharmacy |
| 关键词[WOS] | L. OIL CAKE ; CARTHAMUS-TINCTORIUS ; MONOAMINE TRANSPORTERS ; DOPAMINE TRANSPORTER ; DERIVATIVES ; FLOWERS ; POLLEN ; N-(P-COUMAROYL)SEROTONIN ; SPERMIDINES ; EXTRACT |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000279213500014 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1030]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhao, G,Qin, GW,Gai, Y,et al. Structural Identification of a New Tri-p-coumaroylspermidine with Serotonin Transporter Inhibition from Safflower[J]. CHEMICAL & PHARMACEUTICAL BULLETIN,2010,58(7):950-952. |
| APA | Zhao, G,Qin, GW,Gai, Y,&Guo, LH.(2010).Structural Identification of a New Tri-p-coumaroylspermidine with Serotonin Transporter Inhibition from Safflower.CHEMICAL & PHARMACEUTICAL BULLETIN,58(7),950-952. |
| MLA | Zhao, G,et al."Structural Identification of a New Tri-p-coumaroylspermidine with Serotonin Transporter Inhibition from Safflower".CHEMICAL & PHARMACEUTICAL BULLETIN 58.7(2010):950-952. |
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