Coordinated regulation of active and repressive histone methylations by a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans
文献类型：期刊论文
| 作者 | Lin, HQ; Wang, YQ; Wang, YR; Tian, F; Pu, P; Yu, Y; Mao, HL; Yang, Y; Wang, P; Hu, LL |
| 刊名 | CELL RESEARCH
 |
| 出版日期 | 2010 |
| 卷号 | 20期号:8页码:899-907 |
| 关键词 | KDM7A demethylase H3K9me2 H3K27me2 PHD JmjC histone methylation |
| 通讯作者 | Chen, CD (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai Key Lab Mol Androl,State Key Lab Mol Bio, 320 Yueyang Rd, Shanghai 200031, Peoples R China.,xuyh@fudan.edu.cn ; cdchen@sibs.ac.cn |
| 英文摘要 | H3K9me2 and H3K27me2 are important epigenetic marks associated with transcription repression, while H3K4me3 is associated with transcription activation. It has been shown that active and repressive histone methylations distribute in a mutually exclusive manner, but the underlying mechanism was poorly understood. Here we identified ceKDM7A, a PHD (plant homeodomain)- and JmjC domain-containing protein, as a histone demethylase specific for H3K9me2 and H3K27me2. We further demonstrated that the PHD domain of ceKDM7A bound H3K4me3 and H3K4me3 co-localized with ceKDM7A at the genome-wide level. Disruption of the PHD domain binding to H3K4me3 reduced the demethylase activity in vivo, and loss of ceKDM7A reduced the expression of its associated target genes. These results indicate that ceKDM7A is recruited to the promoter to demethylate H3K9me2 and H3K27me2 and activate gene expression through the binding of the PHD domain to H3K4me3. Thus, our study identifies a dual-specificity histone demethylase and provides novel insights into the regulation of histone methylation. |
| 学科主题 | Cell Biology |
| 类目[WOS] | Cell Biology |
| 关键词[WOS] | CHROMATIN MODIFICATIONS ; GENE REPRESSION ; PHD FINGER ; H3 ; TRANSCRIPTION ; TRIMETHYLATION ; UBIQUITINATION ; DERNETHYLASE ; CROSSTALK ; PROTEINS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000280563100007 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1035]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Lin, HQ,Wang, YQ,Wang, YR,et al. Coordinated regulation of active and repressive histone methylations by a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans[J]. CELL RESEARCH,2010,20(8):899-907. |
| APA | Lin, HQ.,Wang, YQ.,Wang, YR.,Tian, F.,Pu, P.,...&Chen, CD.(2010).Coordinated regulation of active and repressive histone methylations by a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans.CELL RESEARCH,20(8),899-907. |
| MLA | Lin, HQ,et al."Coordinated regulation of active and repressive histone methylations by a dual-specificity histone demethylase ceKDM7A from Caenorhabditis elegans".CELL RESEARCH 20.8(2010):899-907. |
入库方式： OAI收割
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。