Interferon Regulatory Factor 3, A Pivotal Transcription Factor for Host Antiviral Responses
文献类型：期刊论文
| 作者 | Liu, X; Shi, HX; Wang, C |
| 刊名 | PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS
 |
| 出版日期 | 2010 |
| 卷号 | 37期号:8页码:817-825 |
| 关键词 | interferon regulatory factor 3 transcription regulation post-translational modification signal transduction antiviral mechanism |
| 通讯作者 | Wang, C (reprint author), Chinese Acad Sci, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China.,cwang01@sibs.ac.cn |
| 英文摘要 | The innate immune system is the first line of host defense against viruses. Type I interferons (IFNs), the vital antiviral cytokines, play a critical role in establishing host antiviral state. Induction of type I IFN requires the formation of a multi-protein enhanceosome, including three families of key transcription factors (NF-kappa B, IRF3/7, and ATF-2/c-Jun). Transcription factor IRF3 (interferon regulatory factor 3) plays a pivotal role and is tightly regulated in this process. Recently, much progress has been made on cellular signal transduction and regulation of IRF3. Relevant advances in IRF3 biology were summarized with respect to its structure, function and regulatory mechanisms. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | INNATE IMMUNE-RESPONSE ; DOUBLE-STRANDED-RNA ; MEDIATED DEGRADATION ; VIRUS-INFECTION ; IN-VIVO ; NEGATIVE REGULATION ; CRYSTAL-STRUCTURE ; GENE-EXPRESSION ; ACTIVATION ; IRF-3 |
| 收录类别 | SCI |
| 语种 | 中文 |
| WOS记录号 | WOS:000281193900001 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1038]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Liu, X,Shi, HX,Wang, C. Interferon Regulatory Factor 3, A Pivotal Transcription Factor for Host Antiviral Responses[J]. PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,2010,37(8):817-825. |
| APA | Liu, X,Shi, HX,&Wang, C.(2010).Interferon Regulatory Factor 3, A Pivotal Transcription Factor for Host Antiviral Responses.PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS,37(8),817-825. |
| MLA | Liu, X,et al."Interferon Regulatory Factor 3, A Pivotal Transcription Factor for Host Antiviral Responses".PROGRESS IN BIOCHEMISTRY AND BIOPHYSICS 37.8(2010):817-825. |
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