miR-200c affects the mRNA expression of E-cadherin by regulating the mRNA level of TCF8 during post-natal epididymal development in juvenile rats
文献类型：期刊论文
| 作者 | Wang, JF; Ruan, KC |
| 刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
 |
| 出版日期 | 2010 |
| 卷号 | 42期号:9页码:628-634 |
| 关键词 | epididymis miR-200c TCF8 E-cadherin interleukin-2 |
| 通讯作者 | Ruan, KC (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, Shanghai 200031, Peoples R China.,kcruan@sibs.ac.cn |
| 英文摘要 | The unique temporal expression pattern of miR-200c in epididymis during post-natal development in juvenile rats was revealed by our home-made miRNA microarray in this paper. It was found that miR-200c expressed in the lowest level at Day 7 and then increased to the highest at Day 36 followed by a dramatic decrease. The pattern was exactly inverse to that of mRNA expression of transcription factor 8 (TCF8) revealed by quantitative real-time polymerase chain reaction (qRT-PCR), providing an extra evidence that TCF8 is one degradation target of miR-200c even in epididymis. Moreover, the qRT-PCR study on expression of E-cadherin and interleukin-2 indicated that miR-200c does exert an obvious effect on the mRNA expression of E-cadherin by directly regulating the mRNA level of TCF8, although the effect on interleukin-2 is not obvious as on E-cadherin, which implicates that interleukin-2 may be also regulated by other factors besides TCF8 in rat epididymis. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | C-ELEGANS ; CELLS ; MICRORNAS ; DICER ; GENE ; DIFFERENTIATION ; MORPHOGENESIS ; HSA-MIR-200C ; MICROARRAY ; PCR |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000281323400005 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1043]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Wang, JF,Ruan, KC. miR-200c affects the mRNA expression of E-cadherin by regulating the mRNA level of TCF8 during post-natal epididymal development in juvenile rats[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2010,42(9):628-634. |
| APA | Wang, JF,&Ruan, KC.(2010).miR-200c affects the mRNA expression of E-cadherin by regulating the mRNA level of TCF8 during post-natal epididymal development in juvenile rats.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,42(9),628-634. |
| MLA | Wang, JF,et al."miR-200c affects the mRNA expression of E-cadherin by regulating the mRNA level of TCF8 during post-natal epididymal development in juvenile rats".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 42.9(2010):628-634. |
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