Histone deacetylase 1 is required for transforming growth factor-beta 1-induced epithelial-mesenchymal transition
文献类型：期刊论文
| 作者 | Lei, WW; Zhang, KH; Pan, XC; Hu, Y; Wang, DM; Yuan, XW; Shu, GW; Song, JG |
| 刊名 | INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
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| 出版日期 | 2010 |
| 卷号 | 42期号:9页码:1489-1497 |
| 关键词 | HDAC EMT TGF-beta Hepatocytes ZO-1 E-cadherin |
| 通讯作者 | Song, JG (reprint author), Chinese Acad Sci, Mol Cell Biol Lab, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Shanghai 200031, Peoples R China.,jgsong@sibs.ac.cn |
| 英文摘要 | Epithelial-mesenchymal transition (EMT) has been implicated in embryonic development, fibrosis, and tumor metastasis. Histone deacetylases ( HDACs) also play important roles in the control of various physiological and pathological events. However, whether HDACs are involved in the control of EMT in liver cells remains unidentified. Three structurally unrelated HDAC inhibitors completely suppress transforming growth factor-beta 1 (TGF-beta 1)-induced EMT in AML-12 murine hepatocytes and primary mouse hepatocytes. Expression of a dominant-negative mutant of HDAC1 but not HDAC2 or downregulation of HDAC1 but not HDAC2 by RNAi suppressed TGF-beta 1-induced EMT. In addition, both HDAC inhibitor TSA and HDAC1 RNAi blocked cell migration. Overexpression of HDAC1 in invasive hepatocellular carcinoma (HCC) samples was detected. Further study showed that the mRNA levels of ZO-1 and E-cadherin were downregulated during TGF-beta 1 -induced EMT, and HDAC1 can downregulate the promoter activities of ZO-1 and E-cadherin. Conclusions: our results demonstrate that HDAC1 is required for TGF-beta 1-induced EMT and cell migration in hepatocytes. Its high expression levels in majority of invasive HCC samples suggest that, by promoting EMT, HDAC1 can be related with the invasiveness of HCC. The data also suggest that the repression of transcription of ZO-1 and E-cadherin by HDAC1 may be involved in TGF-beta 1-induced EMT. (C) 2010 Elsevier Ltd. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology; Cell Biology |
| 类目[WOS] | Biochemistry & Molecular Biology ; Cell Biology |
| 关键词[WOS] | HEPATOCELLULAR-CARCINOMA CELLS ; REGULATES E-CADHERIN ; TUMOR-METASTASIS ; ZONULA OCCLUDENS-1 ; OXIDATIVE STRESS ; HEPATOMA-CELLS ; LIVER FIBROSIS ; EXPRESSION ; INHIBITOR ; PROTEIN |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000280967700016 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1049]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Lei, WW,Zhang, KH,Pan, XC,et al. Histone deacetylase 1 is required for transforming growth factor-beta 1-induced epithelial-mesenchymal transition[J]. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY,2010,42(9):1489-1497. |
| APA | Lei, WW.,Zhang, KH.,Pan, XC.,Hu, Y.,Wang, DM.,...&Song, JG.(2010).Histone deacetylase 1 is required for transforming growth factor-beta 1-induced epithelial-mesenchymal transition.INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY,42(9),1489-1497. |
| MLA | Lei, WW,et al."Histone deacetylase 1 is required for transforming growth factor-beta 1-induced epithelial-mesenchymal transition".INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY 42.9(2010):1489-1497. |
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