Dishevelled interacts with p65 and acts as a repressor of NF-kappa B-mediated transcription
文献类型：期刊论文
| 作者 | Deng, N; Ye, YE; Wang, W; Li, L |
| 刊名 | CELL RESEARCH
 |
| 出版日期 | 2010 |
| 卷号 | 20期号:10页码:1117-1127 |
| 关键词 | Dishevelled (Dvl) NF-kappa B p65 transcriptional suppressor Wnt signaling |
| 通讯作者 | Li, L (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, Shanghai 200031, Peoples R China.,lli@sibs.ac.cn |
| 英文摘要 | Dishevelled (Dvl) is a highly conserved protein family that plays an important role in mediating Wnt signaling from membrane to cytoplasm. Recently we reported that Dvl also functions in the nucleus by stabilizing the beta-catenin/TCFs transcriptional complex. Here we describe that Dvl may function as a repressor of NF-kappa B. Our data show that Dvl directly binds to p65 and their interaction occurs in the nucleus. Dvl expression inhibits p65-mediated or TNF-alpha-stimulated activation of the NF-kappa B dependent reporter. This action of Dvl, however, is not dependent on Wnt or its downstream effector beta-catenin. Chromatin immunoprecipitation assay shows that recruitment of p65 to the promoters of NF-kappa B target genes is significantly enhanced when expression of Dvl is knocked down. Consistently, the expression level of a subset of NF-kappa B target genes is also increased after knock-down of Dvl. Moreover, our data suggest that Dvl may relieve the anti-apoptotic effect of NF-kappa B, thus play a role in promoting apoptosis. Therefore, this work demonstrates a novel function of Dvl in modulating NF-kappa B-regulated gene transcription. |
| 学科主题 | Cell Biology |
| 类目[WOS] | Cell Biology |
| 关键词[WOS] | BETA-CATENIN ; SIGNALING PATHWAYS ; INDUCED APOPTOSIS ; CELL POLARITY ; C-JUN ; PROTEINS ; CANCER ; A20 ; ACTIVATION ; MECHANISMS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000283397100007 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1057]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Deng, N,Ye, YE,Wang, W,et al. Dishevelled interacts with p65 and acts as a repressor of NF-kappa B-mediated transcription[J]. CELL RESEARCH,2010,20(10):1117-1127. |
| APA | Deng, N,Ye, YE,Wang, W,&Li, L.(2010).Dishevelled interacts with p65 and acts as a repressor of NF-kappa B-mediated transcription.CELL RESEARCH,20(10),1117-1127. |
| MLA | Deng, N,et al."Dishevelled interacts with p65 and acts as a repressor of NF-kappa B-mediated transcription".CELL RESEARCH 20.10(2010):1117-1127. |
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