Asc1, a WD-repeat protein, is required for hyphal development and virulence in Candida albicans
文献类型：期刊论文
| 作者 | Liu, XY; Nie, XY; Ding, YF; Chen, JY |
| 刊名 | ACTA BIOCHIMICA ET BIOPHYSICA SINICA
 |
| 出版日期 | 2010 |
| 卷号 | 42期号:11页码:793-800 |
| 关键词 | Candida albicans Asc1 hyphal development virulence |
| 通讯作者 | Chen, JY (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, State Key Lab Mol Biol, Shanghai 200031, Peoples R China.,jychen@sibs.ac.cn |
| 英文摘要 | Candida albicans is a human pathogenic fungus which can undergo a morphological transition from yeast to hyphae in response to a variety of environmental stimuli. We analyzed a C. albicans Asc1 (Absence of growth Suppressor of Cyp1) protein which is entirely composed of seven repeats of the WD domain, and is conserved from fungi to metazoan. Deleting the ASC1 in C. albicans led to a profound defect in hyphal development under hypha-inducing conditions examined. Furthermore, deletion of the ASC1 attenuated virulence of C. albicans in a mouse model of systemic infection. These data strongly suggested that the conserved WD-repeat protein Asc1 is required for morphogenesis and pathogenesis of C. albicans. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics |
| 关键词[WOS] | AMINO-ACID STARVATION ; SACCHAROMYCES-CEREVISIAE ; MAMMALIAN RACK1 ; TRANSCRIPTION FACTOR ; SIGNAL-TRANSDUCTION ; FILAMENTOUS GROWTH ; IN-VIVO ; YEAST ; KINASE ; GENE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000283657600005 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1065]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Liu, XY,Nie, XY,Ding, YF,et al. Asc1, a WD-repeat protein, is required for hyphal development and virulence in Candida albicans[J]. ACTA BIOCHIMICA ET BIOPHYSICA SINICA,2010,42(11):793-800. |
| APA | Liu, XY,Nie, XY,Ding, YF,&Chen, JY.(2010).Asc1, a WD-repeat protein, is required for hyphal development and virulence in Candida albicans.ACTA BIOCHIMICA ET BIOPHYSICA SINICA,42(11),793-800. |
| MLA | Liu, XY,et al."Asc1, a WD-repeat protein, is required for hyphal development and virulence in Candida albicans".ACTA BIOCHIMICA ET BIOPHYSICA SINICA 42.11(2010):793-800. |
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