AMP-activated protein kinase is required for induction of apoptosis and epithelial-to-mesenchymal transition
文献类型：期刊论文
| 作者 | Wang, XD; Pan, XC; Song, JG |
| 刊名 | CELLULAR SIGNALLING
 |
| 出版日期 | 2010 |
| 卷号 | 22期号:11页码:1790-1797 |
| 关键词 | AMP-activated protein kinase TGF-beta Epithelial-to-mesenchymal transition Apoptosis |
| 通讯作者 | Song, JG (reprint author), 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,jgsong@sibs.ac.cn |
| 英文摘要 | AMP-activated protein kinase (AMPK) is a serine/threonine protein kinase which has been implicated in the regulation of cellular energy homeostasis. Relatively very little is known about its role in other cellular processes. We observed that AMPK-alpha can be activated by transforming growth factor-beta 1 (TGF-beta 1) in mouse hepatocytes. Inhibition of AMPK by Compound C, a selective AMPK-alpha inhibitor, inhibited TGF-beta 1-induced apoptosis and EMT in hepatocytes. In addition, overexpression of a dominant-negative form of AMPK-alpha subunit also suppressed TGF-beta 1-induced EMT and apoptosis in AML12 cells. Furthermore, inhibition of AMPK suppressed TGF-beta 1-induced Smad3 transcriptional activity. This study indicates that AMPK is able to modulate Smad3 transcriptional activity, which plays an important role in TGF-beta 1-induced apoptosis and EMT. (C) 2010 Elsevier Inc. All rights reserved. |
| 学科主题 | Cell Biology |
| 类目[WOS] | Cell Biology |
| 关键词[WOS] | GROWTH-FACTOR-BETA ; FATTY-ACID OXIDATION ; TGF-BETA ; TUMOR SUPPRESSION ; LIVER ; FIBROSIS ; METABOLISM ; UPSTREAM ; PATHWAY ; CELLS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000281463500022 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1069]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Wang, XD,Pan, XC,Song, JG. AMP-activated protein kinase is required for induction of apoptosis and epithelial-to-mesenchymal transition[J]. CELLULAR SIGNALLING,2010,22(11):1790-1797. |
| APA | Wang, XD,Pan, XC,&Song, JG.(2010).AMP-activated protein kinase is required for induction of apoptosis and epithelial-to-mesenchymal transition.CELLULAR SIGNALLING,22(11),1790-1797. |
| MLA | Wang, XD,et al."AMP-activated protein kinase is required for induction of apoptosis and epithelial-to-mesenchymal transition".CELLULAR SIGNALLING 22.11(2010):1790-1797. |
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