Interferon regulatory factor 4 regulates thymocyte differentiation by repressing Runx3 expression
文献类型：期刊论文
| 作者 | Cao, YH; Li, H; Sun, Y; Chen, XF; Liu, HF; Gao, XA; Liu, XL |
| 刊名 | EUROPEAN JOURNAL OF IMMUNOLOGY
 |
| 出版日期 | 2010 |
| 卷号 | 40期号:11页码:3198-3209 |
| 关键词 | Deacetylation IRF4 Lineage differentiation Runx3 Thymocyte |
| 通讯作者 | Liu, XL (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, Shanghai 200031, Peoples R China.,liux@sibs.ac.cn |
| 英文摘要 | The transcription factor interferon regulatory factor 4 (IRF4) was originally found to be preferentially expressed in lymphoid cells and to be required for the function, differentiation, and homeostasis of both mature T and B lymphocytes. Recent studies have indicated that IRF4 is also involved in early B-cell development. However, the role of IRF4 in intrathymic T-cell development remains unknown. In this study, we show that IRF4 is upregulated in TCR-signaled thymocytes and is predominantly expressed in CD4 single-positive (SP), but not in CD8 SP, cells. T-cell-specific overexpression of IRF4 impaired the generation and maturation of CD8 SP thymocytes. Further analysis revealed that IRF4 selectively bound to the distal promoter region of Runx3 and repressed its transcription, probably through the deacetylation of histones H3 and H4 in intermediate CD4(+) CD8(low) cells and CD4 SP thymocytes. Similar to the effect of Runx3 deficiency, transgenic expression of IRF4 led not only to an aberrantly high expression of CD4 surface molecules on intermediate CD4(+) CD8(low) cells and CD8 SP thymocytes, but also impaired CD8(+) T-cell function. Taken together, our data suggest that IRF4 plays an important role in the regulation of Runx3 expression and CD4(+)/CD8(+) thymocyte differentiation. |
| 学科主题 | Immunology |
| 类目[WOS] | Immunology |
| 关键词[WOS] | T-CELL DEVELOPMENT ; HELPER TYPE-1 CELLS ; TRANSCRIPTION FACTOR ; LINEAGE DIFFERENTIATION ; IRF FAMILY ; CD4 ; THPOK ; GENE ; COMMITMENT ; ACTIVATION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000284059000024 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1070]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Cao, YH,Li, H,Sun, Y,et al. Interferon regulatory factor 4 regulates thymocyte differentiation by repressing Runx3 expression[J]. EUROPEAN JOURNAL OF IMMUNOLOGY,2010,40(11):3198-3209. |
| APA | Cao, YH.,Li, H.,Sun, Y.,Chen, XF.,Liu, HF.,...&Liu, XL.(2010).Interferon regulatory factor 4 regulates thymocyte differentiation by repressing Runx3 expression.EUROPEAN JOURNAL OF IMMUNOLOGY,40(11),3198-3209. |
| MLA | Cao, YH,et al."Interferon regulatory factor 4 regulates thymocyte differentiation by repressing Runx3 expression".EUROPEAN JOURNAL OF IMMUNOLOGY 40.11(2010):3198-3209. |
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