Immune Protection Induced on Day 10 Following Administration of the 2009 A/H1N1 Pandemic Influenza Vaccine
文献类型：期刊论文
| 作者 | Sun, YZ; Bian, C; Xu, K; Hu, WB; Wang, TY; Cui, J; Wu, HQ; Ling, ZY; Ji, YY; Lin, GM |
| 刊名 | PLOS ONE
 |
| 出版日期 | 2010 |
| 卷号 | 5期号:12页码:e14270-e14270 |
| 通讯作者 | Sun, YZ (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Key Lab Mol Cell Biol, Shanghai, Peoples R China.,mxwhualan@126.com ; bsun@sibs.ac.cn |
| 英文摘要 | Background: The 2009 swine-origin influenza virus (S-OIV) H1N1 pandemic has caused more than 18,000 deaths worldwide. Vaccines against the 2009 A/H1N1 influenza virus are useful for preventing infection and controlling the pandemic. The kinetics of the immune response following vaccination with the 2009 A/H1N1 influenza vaccine need further investigation. Methodology/Principal Findings: 58 volunteers were vaccinated with a 2009 A/H1N1 pandemic influenza monovalent split-virus vaccine (15 mu g, single-dose). The sera were collected before Day 0 (pre-vaccination) and on Days 3, 5, 10, 14, 21, 30, 45 and 60 post vaccination. Specific antibody responses induced by the vaccination were analyzed using hemagglutination inhibition (HI) assay and enzyme-linked immunosorbent assay (ELISA). After administration of the 2009 A/H1N1 influenza vaccine, specific and protective antibody response with a major subtype of IgG was sufficiently developed as early as Day 10 (seroprotection rate: 93%). This specific antibody response could maintain for at least 60 days without significant reduction. Antibody response induced by the 2009 A/H1N1 influenza vaccine could not render protection against seasonal H1N1 influenza (seroconversion rate: 3% on Day 21). However, volunteers with higher pre-existing seasonal influenza antibody levels (pre-vaccination HI titer >= 1:40, Group 1) more easily developed a strong antibody protection effect against the 2009 A/H1N1 influenza vaccine as compared with those showing lower pre-existing seasonal influenza antibody levels (pre-vaccination HI titer <1:40, Group 2). The titer of the specific antibody against the 2009 A/H1N1 influenza was much higher in Group 1 (geometric mean titer: 146 on Day 21) than that in Group 2 (geometric mean titer: 70 on Day 21). Conclusions/Significance: Recipients could gain sufficient protection as early as 10 days after vaccine administration. The protection could last at least 60 days. Individuals with a stronger pre-existing seasonal influenza antibody response may have a relatively higher potential for developing a stronger humoral immune response after vaccination with the 2009 A/H1N1 pandemic influenza vaccine. |
| 学科主题 | Science & Technology - Other Topics |
| 类目[WOS] | Multidisciplinary Sciences |
| 关键词[WOS] | A H1N1 VACCINE ; VIRUS ; ANTIBODY ; EMERGENCE ; RESPONSES ; HUMANS |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000285135800006 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1073]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Sun, YZ,Bian, C,Xu, K,et al. Immune Protection Induced on Day 10 Following Administration of the 2009 A/H1N1 Pandemic Influenza Vaccine[J]. PLOS ONE,2010,5(12):e14270-e14270. |
| APA | Sun, YZ.,Bian, C.,Xu, K.,Hu, WB.,Wang, TY.,...&Sun, B.(2010).Immune Protection Induced on Day 10 Following Administration of the 2009 A/H1N1 Pandemic Influenza Vaccine.PLOS ONE,5(12),e14270-e14270. |
| MLA | Sun, YZ,et al."Immune Protection Induced on Day 10 Following Administration of the 2009 A/H1N1 Pandemic Influenza Vaccine".PLOS ONE 5.12(2010):e14270-e14270. |
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