The Dual Histone Demethylase KDM7A Promotes Neural Induction in Early Chick Embryos
文献类型：期刊论文
| 作者 | Huang, CY; Chen, J; Zhang, T; Zhu, QQ; Xiang, Y; Chen, CD; Jing, NH |
| 刊名 | DEVELOPMENTAL DYNAMICS
 |
| 出版日期 | 2010 |
| 卷号 | 239期号:12页码:3350-3357 |
| 关键词 | neural induction chick embryo histone demethylase KDM7A FGF4 |
| 通讯作者 | Jing, NH (reprint author), Chinese Acad Sci, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Mol Cell Biol Lab, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,cdchen@sibs.ac.cn ; njing@sibs.ac.cn |
| 英文摘要 | Neural induction is the initial event of nervous system development during which part of the ectoderm is specified to become the embryonic neural plate. The biological roles of histone modification enzymes in the neural induction of early embryos remain unclear. Here, we show that an evolutionarily conserved dual histone demethylase KDM7A (KIAA1718) is predominantly expressed in epiblast cells of the primitive streak in early chick embryos. Overexpression of KDM7A in chick embryos leads to expansion of the neural plate, whereas knockdown of the gene impairs formation of the neural plate. We also show that KDM7A regulates Fgf4 expression in the primitive streak and that co-electroporation of a chick Fgf4 expression vector with KDM7A siRNA rescues the neural induction defect in chick embryos. Taken together, these results reveal an important role for histone demethylases in the determination of neural fate, and they highlight the mechanistic complexity of neural induction in early embryos. Developmental Dynamics 239:3350-3357, 2010. (C) 2010 Wiley-Liss, Inc. |
| 学科主题 | Anatomy & Morphology; Developmental Biology |
| 类目[WOS] | Anatomy & Morphology ; Developmental Biology |
| 关键词[WOS] | BMP INHIBITION ; STEM-CELL ; FGF ; EXPRESSION ; SOX2 ; DIFFERENTIATION ; GASTRULATION ; SPECIFICITY ; REPRESSION ; FAMILY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000284783100020 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1079]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Huang, CY,Chen, J,Zhang, T,et al. The Dual Histone Demethylase KDM7A Promotes Neural Induction in Early Chick Embryos[J]. DEVELOPMENTAL DYNAMICS,2010,239(12):3350-3357. |
| APA | Huang, CY.,Chen, J.,Zhang, T.,Zhu, QQ.,Xiang, Y.,...&Jing, NH.(2010).The Dual Histone Demethylase KDM7A Promotes Neural Induction in Early Chick Embryos.DEVELOPMENTAL DYNAMICS,239(12),3350-3357. |
| MLA | Huang, CY,et al."The Dual Histone Demethylase KDM7A Promotes Neural Induction in Early Chick Embryos".DEVELOPMENTAL DYNAMICS 239.12(2010):3350-3357. |
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