中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
The Dual Histone Demethylase KDM7A Promotes Neural Induction in Early Chick Embryos

文献类型:期刊论文

作者Huang, CY; Chen, J; Zhang, T; Zhu, QQ; Xiang, Y; Chen, CD; Jing, NH
刊名DEVELOPMENTAL DYNAMICS
出版日期2010
卷号239期号:12页码:3350-3357
关键词neural induction chick embryo histone demethylase KDM7A FGF4
通讯作者Jing, NH (reprint author), Chinese Acad Sci, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, Mol Cell Biol Lab, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,cdchen@sibs.ac.cn ; njing@sibs.ac.cn
英文摘要Neural induction is the initial event of nervous system development during which part of the ectoderm is specified to become the embryonic neural plate. The biological roles of histone modification enzymes in the neural induction of early embryos remain unclear. Here, we show that an evolutionarily conserved dual histone demethylase KDM7A (KIAA1718) is predominantly expressed in epiblast cells of the primitive streak in early chick embryos. Overexpression of KDM7A in chick embryos leads to expansion of the neural plate, whereas knockdown of the gene impairs formation of the neural plate. We also show that KDM7A regulates Fgf4 expression in the primitive streak and that co-electroporation of a chick Fgf4 expression vector with KDM7A siRNA rescues the neural induction defect in chick embryos. Taken together, these results reveal an important role for histone demethylases in the determination of neural fate, and they highlight the mechanistic complexity of neural induction in early embryos. Developmental Dynamics 239:3350-3357, 2010. (C) 2010 Wiley-Liss, Inc.
学科主题Anatomy & Morphology; Developmental Biology
类目[WOS]Anatomy & Morphology ; Developmental Biology
关键词[WOS]BMP INHIBITION ; STEM-CELL ; FGF ; EXPRESSION ; SOX2 ; DIFFERENTIATION ; GASTRULATION ; SPECIFICITY ; REPRESSION ; FAMILY
收录类别SCI
语种英语
WOS记录号WOS:000284783100020
版本出版稿
源URL[http://202.127.25.143/handle/331003/1079]  
专题上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式
GB/T 7714
Huang, CY,Chen, J,Zhang, T,et al. The Dual Histone Demethylase KDM7A Promotes Neural Induction in Early Chick Embryos[J]. DEVELOPMENTAL DYNAMICS,2010,239(12):3350-3357.
APA Huang, CY.,Chen, J.,Zhang, T.,Zhu, QQ.,Xiang, Y.,...&Jing, NH.(2010).The Dual Histone Demethylase KDM7A Promotes Neural Induction in Early Chick Embryos.DEVELOPMENTAL DYNAMICS,239(12),3350-3357.
MLA Huang, CY,et al."The Dual Histone Demethylase KDM7A Promotes Neural Induction in Early Chick Embryos".DEVELOPMENTAL DYNAMICS 239.12(2010):3350-3357.

入库方式: OAI收割

来源:上海生物化学与细胞生物学研究所

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