Coevolution is a short-distance force at the protein interaction level and correlates with the modular organization of protein networks
文献类型：期刊论文
| 作者 | Liang, Z; Xu, M; Teng, MK; Niu, LW; Wu, JR |
| 刊名 | FEBS LETTERS
 |
| 出版日期 | 2010 |
| 卷号 | 584期号:19页码:4237-4240 |
| 关键词 | Protein-protein interaction Protein interaction network Coevolution Modularity |
| 通讯作者 | Liang, Z (reprint author), Univ Sci & Technol China, Hefei Natl Lab Phys Sci Microscale, Hefei 230027, Anhui, Peoples R China.,liangzhi@ustc.edu.cn ; wujr@sibs.ac.cn |
| 英文摘要 | We investigated what roles coevolution plays in shaping yeast protein interaction network (PIN). We found that the extent of coevolution between two proteins decreases rapidly as their interacting distance on the PIN increases, suggesting coevolutionary constraint is a short-distance force at the molecular level. We also found that protein-protein interactions (PPIs) with strong coevolution tend to be enriched in interconnected clusters, whereas PPIs with weak coevolution are more frequently present at inter-cluster region. The findings indicate the close relationship between coevolution and modular organization of PINs, and may provide insights into evolution and modularity of cellular networks. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics; Cell Biology |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
| 关键词[WOS] | GENE-EXPRESSION ; BINDING-PROTEIN ; SPECIFICITY ; PHYLOGENY ; COMMUNITY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000282360800020 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1086]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Liang, Z,Xu, M,Teng, MK,et al. Coevolution is a short-distance force at the protein interaction level and correlates with the modular organization of protein networks[J]. FEBS LETTERS,2010,584(19):4237-4240. |
| APA | Liang, Z,Xu, M,Teng, MK,Niu, LW,&Wu, JR.(2010).Coevolution is a short-distance force at the protein interaction level and correlates with the modular organization of protein networks.FEBS LETTERS,584(19),4237-4240. |
| MLA | Liang, Z,et al."Coevolution is a short-distance force at the protein interaction level and correlates with the modular organization of protein networks".FEBS LETTERS 584.19(2010):4237-4240. |
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