Glucocorticoid induces mesenchymal-to-epithelial transition and inhibits TGF-beta 1-induced epithelial-to-mesenchymal transition and cell migration
文献类型：期刊论文
| 作者 | Zhang, LA; Lei, WW; Wang, XD; Tang, YN; Song, JG |
| 刊名 | FEBS LETTERS
 |
| 出版日期 | 2010 |
| 卷号 | 584期号:22页码:4646-4654 |
| 关键词 | Epithelial-to-mesenchymal transition Mesenchymal-to-epithelial transition Snail Transforming growth factor-beta Glucocorticoid Reactive oxygen species |
| 通讯作者 | Song, JG (reprint author), Chinese Acad Sci, Mol Cell Biol Lab, Inst Biochem & Cell Biol, Shanghai Inst Biol Sci, 320 Yue Yang Rd, Shanghai 200031, Peoples R China.,jgsong@sibs.ac.cn |
| 英文摘要 | Epithelial-to-mesenchymal transition (EMT) has been implicated in various physiological and pathological events. In this study, we found that the synthetic glucocorticoid dexamethasone (Dex) can inhibit transforming growth factor-beta1-induced EMT and cell migration. We also demonstrated that Dex inhibits EMT through a mechanism involving the suppression of ROS generation. Surprisingly, Dex alone induced mesenchymal-to-epithelial transition (MET). Dexamethasone treatment abolished Snail1 binding to the E-cadherin promoter, suggesting that suppression of Snail1 contributes to the above roles of Dex. Our findings demonstrate that Dex functions as both a suppressor of EMT and as an inducer of MET and therefore may be implicated in certain pathophysiological events. (C) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved. |
| 学科主题 | Biochemistry & Molecular Biology; Biophysics; Cell Biology |
| 类目[WOS] | Biochemistry & Molecular Biology ; Biophysics ; Cell Biology |
| 关键词[WOS] | GROWTH-FACTOR-BETA ; ACTIVATED PROTEIN-KINASE ; TRANSCRIPTION FACTOR SNAIL ; E-CADHERIN EXPRESSION ; TGF-BETA ; CANCER PROGRESSION ; TUMOR PROGRESSION ; GENE-EXPRESSION ; CLEFT-PALATE ; DEXAMETHASONE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000284148000026 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1089]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, LA,Lei, WW,Wang, XD,et al. Glucocorticoid induces mesenchymal-to-epithelial transition and inhibits TGF-beta 1-induced epithelial-to-mesenchymal transition and cell migration[J]. FEBS LETTERS,2010,584(22):4646-4654. |
| APA | Zhang, LA,Lei, WW,Wang, XD,Tang, YN,&Song, JG.(2010).Glucocorticoid induces mesenchymal-to-epithelial transition and inhibits TGF-beta 1-induced epithelial-to-mesenchymal transition and cell migration.FEBS LETTERS,584(22),4646-4654. |
| MLA | Zhang, LA,et al."Glucocorticoid induces mesenchymal-to-epithelial transition and inhibits TGF-beta 1-induced epithelial-to-mesenchymal transition and cell migration".FEBS LETTERS 584.22(2010):4646-4654. |
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