Influenza A Virus Replication Induces Cell Cycle Arrest in G(0)/G(1) Phase
文献类型：期刊论文
| 作者 | He, YA; Xu, K; Keiner, B; Zhou, JF; Czudai, V; Li, TX; Chen, Z; Liu, JH; Klenk, HD; Shu, YL |
| 刊名 | JOURNAL OF VIROLOGY
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| 出版日期 | 2010 |
| 卷号 | 84期号:24页码:12832-12840 |
| 通讯作者 | Shu, YL (reprint author), Chinese Ctr Dis Control & Prevent, Yingxin St 100, Beijing 100052, Peoples R China.,yshu@vip.sina.com ; bsun@sibs.ac.cn |
| 英文摘要 | Many viruses interact with the host cell division cycle to favor their own growth. In this study, we examined the ability of influenza A virus to manipulate cell cycle progression. Our results show that influenza A virus A/WSN/33 ( H1N1) replication results in G(0)/G(1)-phase accumulation of infected cells and that this accumulation is caused by the prevention of cell cycle entry from G(0)/G(1) phase into S phase. Consistent with the G(0)/G(1)-phase accumulation, the amount of hyperphosphorylated retinoblastoma protein, a necessary active form for cell cycle progression through late G(1) into S phase, decreased after infection with A/WSN/33 ( H1N1) virus. In addition, other key molecules in the regulation of the cell cycle, such as p21, cyclin E, and cyclin D1, were also changed and showed a pattern of G(0)/G(1)-phase cell cycle arrest. It is interesting that increased viral protein expression and progeny virus production in cells synchronized in the G(0)/G(1) phase were observed compared to those in either unsynchronized cells or cells synchronized in the G(2)/M phase. G(0)/G(1)-phase cell cycle arrest is likely a common strategy, since the effect was also observed in other strains, such as H3N2, H9N2, PR8 H1N1, and pandemic swine H1N1 viruses. These findings, in all, suggest that influenza A virus may provide favorable conditions for viral protein accumulation and virus production by inducing a G(0)/G(1)-phase cell cycle arrest in infected cells. |
| 学科主题 | Virology |
| 类目[WOS] | Virology |
| 关键词[WOS] | CAP-DEPENDENT TRANSLATION ; LARGE TUMOR-ANTIGEN ; RETINOBLASTOMA PROTEIN ; DEATH APOPTOSIS ; D3/PRB PATHWAY ; INFECTED-CELLS ; P53 ; HEMAGGLUTININ ; TRANSCRIPTION ; PROGRESSION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000284469600036 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1091]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | He, YA,Xu, K,Keiner, B,et al. Influenza A Virus Replication Induces Cell Cycle Arrest in G(0)/G(1) Phase[J]. JOURNAL OF VIROLOGY,2010,84(24):12832-12840. |
| APA | He, YA.,Xu, K.,Keiner, B.,Zhou, JF.,Czudai, V.,...&Sun, B.(2010).Influenza A Virus Replication Induces Cell Cycle Arrest in G(0)/G(1) Phase.JOURNAL OF VIROLOGY,84(24),12832-12840. |
| MLA | He, YA,et al."Influenza A Virus Replication Induces Cell Cycle Arrest in G(0)/G(1) Phase".JOURNAL OF VIROLOGY 84.24(2010):12832-12840. |
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