Retinoic acid regulates bone morphogenic protein signal duration by promoting the degradation of phosphorylated Smad1
文献类型：期刊论文
| 作者 | Sheng, NY; Xie, ZH; Wang, C; Bai, G; Zhang, KJ; Zhu, QQ; Song, JG; Guillemot, F; Chen, YG; Lin, AN |
| 刊名 | PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
 |
| 出版日期 | 2010 |
| 卷号 | 107期号:44页码:18886-18891 |
| 通讯作者 | Jing, NH (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Mol Cell Biol Lab, Shanghai 200031, Peoples R China.,njing@sibs.ac.cn |
| 英文摘要 | The proper function of the bone morphogenic protein (BMP) pathway during embryonic development and organ maintenance requires its communication with other signaling pathways. Unlike the well-documented regulation of the BMP pathway by FGF/MAPK and Wnt/GSK3 signals, cross-talk between BMP/Smad and retinoic acid (RA)/RA receptor (RAR) pathways is poorly understood. Here, we show that RA represses BMP signal duration by reducing the level of phosphorylated Smad1 (pSmad1). Through its nuclear receptor-mediated transcription, RA enhances the interaction between pSmad1 and its ubiquitin E3 ligases, thereby promoting pSmad1 ubiquitination and proteasomal degradation. This regulation depends on the RA-increased Gadd45 expression and MAPK activation. During the neural development in chicken embryo, the RA/RAR pathway also suppresses BMP signaling to antagonize BMP-regulated proliferation and differentiation of neural progenitor cells. Furthermore, this cross-talk between RA and BMP pathways is involved in the proper patterning of dorsal neural tube of chicken embryo. Our results reveal a mechanism by which RA suppresses BMP signaling through regulation of pSmad1 stability. |
| 学科主题 | Science & Technology - Other Topics |
| 类目[WOS] | Multidisciplinary Sciences |
| 关键词[WOS] | E3 UBIQUITIN LIGASES ; DORSAL SPINAL-CORD ; TGF-BETA ; NERVOUS-SYSTEM ; TRANSCRIPTIONAL ACTIVATION ; CELL-TYPES ; BMP ; RECEPTORS ; PATHWAYS ; FAMILY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000283749000030 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1097]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Sheng, NY,Xie, ZH,Wang, C,et al. Retinoic acid regulates bone morphogenic protein signal duration by promoting the degradation of phosphorylated Smad1[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2010,107(44):18886-18891. |
| APA | Sheng, NY.,Xie, ZH.,Wang, C.,Bai, G.,Zhang, KJ.,...&Jing, NH.(2010).Retinoic acid regulates bone morphogenic protein signal duration by promoting the degradation of phosphorylated Smad1.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,107(44),18886-18891. |
| MLA | Sheng, NY,et al."Retinoic acid regulates bone morphogenic protein signal duration by promoting the degradation of phosphorylated Smad1".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 107.44(2010):18886-18891. |
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