Acyl-coenzyme A: cholesterol acyltransferases
文献类型：期刊论文
| 作者 | Chang, TY; Li, BL; Chang, CCY; Urano, Y |
| 刊名 | AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM
 |
| 出版日期 | 2009 |
| 卷号 | 297期号:1页码:E1-E9 |
| 关键词 | acyl-coenzyme A: cholesterol acyltransferase inhibitors atherosclerosis Alzheimer's disease |
| 通讯作者 | Chang, TY (reprint author), Dartmouth Med Sch, Dept Biochem, 1 Rope Ferry Rd, Hanover, NH 03755 USA.,Ta.Yuan.Chang@Dartmouth.edu |
| 英文摘要 | Chang TY, Li BL, Chang CC, Urano Y. Acyl-coenzyme A: cholesterol acyltransferases. Am J Physiol Endocrinol Metab 297: E1-E9, 2009. First published January 13, 2009; doi:10.1152/ajpendo.90926.2008.-The enzymes acylcoenzyme A (CoA): cholesterol acyltransferases (ACATs) are membrane-bound proteins that utilize long-chain fatty acyl-CoA and cholesterol as substrates to form cholesteryl esters. In mammals, two isoenzymes, ACAT1 and ACAT2, encoded by two different genes, exist. ACATs play important roles in cellular cholesterol homeostasis in various tissues. This chapter summarizes the current knowledge on ACAT-related research in two areas: 1) ACAT genes and proteins and 2) ACAT enzymes as drug targets for atherosclerosis and for Alzheimer's disease. |
| 学科主题 | Endocrinology & Metabolism; Physiology |
| 类目[WOS] | Endocrinology & Metabolism ; Physiology |
| 关键词[WOS] | MONOCYTE-DERIVED MACROPHAGES ; HAMSTER OVARY CELLS ; E-DEFICIENT MICE ; ISOFORM-SPECIFIC INHIBITOR ; 2 DIFFERENT CHROMOSOMES ; ACAT INHIBITOR ; IN-VITRO ; ATHEROSCLEROTIC LESIONS ; ENDOPLASMIC-RETICULUM ; ALZHEIMERS-DISEASE |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000268250900001 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1119]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Chang, TY,Li, BL,Chang, CCY,et al. Acyl-coenzyme A: cholesterol acyltransferases[J]. AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM,2009,297(1):E1-E9. |
| APA | Chang, TY,Li, BL,Chang, CCY,&Urano, Y.(2009).Acyl-coenzyme A: cholesterol acyltransferases.AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM,297(1),E1-E9. |
| MLA | Chang, TY,et al."Acyl-coenzyme A: cholesterol acyltransferases".AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 297.1(2009):E1-E9. |
入库方式： OAI收割
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