The androgen receptor in hormone-refractory prostate cancer
文献类型：期刊论文
| 作者 | Mao, HL; Zhu, ZQ; Chen, CD |
| 刊名 | ASIAN JOURNAL OF ANDROLOGY
 |
| 出版日期 | 2009 |
| 卷号 | 11期号:1页码:68-73 |
| 关键词 | prostate cancer hormone therapy androgen receptor hormone-refractory prostate cancer |
| 通讯作者 | Chen, CD (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai Key Lab Androl,State Key Lab Mol Biol, 320 Yueyang Rd, Shanghai 200031, Peoples R China.,cdchen@sibs.ac.cn |
| 英文摘要 | Advanced prostate cancer is responsive to hormone therapy that interferes with androgen receptor (AR) signalling. However, the effect is short-lived, as nearly all tumours progress to a hormone-refractory (HR) state, a lethal stage of the disease. Intuitively, the AR should not be involved because hormone therapy that blocks or reduces AR activity is not effective in treating HR tumours. However, there is still a consensus that AR plays an essential role in HR prostate cancer (HRPC) because AR signalling is still functional in HR tumours. AR signalling can be activated in HR tumours through several mechanisms. First, activation of intracellular signal transduction pathways can sensitize the AR to castrate levels of androgens. Also, mutations in the AR can change AR ligand specificity, thereby allowing it to be activated by non-steroids or anti-androgens. Finally, overexpression of the wild-type AR sensitizes itself to low concentrations of androgens. Therefore, drugs targeting AR signalling could still be effective in treating HRPC. |
| 学科主题 | Endocrinology & Metabolism; Urology & Nephrology |
| 类目[WOS] | Andrology ; Urology & Nephrology |
| 关键词[WOS] | STEROID BINDING CHARACTERISTICS ; GROWTH-FACTOR-I ; INCREASED EXPRESSION ; CELLS ; GENE ; AMPLIFICATION ; ACTIVATION ; CARCINOMA ; MUTATION ; THERAPY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000262866800010 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1125]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Mao, HL,Zhu, ZQ,Chen, CD. The androgen receptor in hormone-refractory prostate cancer[J]. ASIAN JOURNAL OF ANDROLOGY,2009,11(1):68-73. |
| APA | Mao, HL,Zhu, ZQ,&Chen, CD.(2009).The androgen receptor in hormone-refractory prostate cancer.ASIAN JOURNAL OF ANDROLOGY,11(1),68-73. |
| MLA | Mao, HL,et al."The androgen receptor in hormone-refractory prostate cancer".ASIAN JOURNAL OF ANDROLOGY 11.1(2009):68-73. |
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