Inhibition of renal cancer cell growth by oncolytic adenovirus armed short hairpin RNA targeting hTERT gene
文献类型：期刊论文
| 作者 | Zheng, JN; Pei, DS; Sun, FH; Zhang, BF; Liu, XY; Gu, JF; Liu, YH; Hu, XL; Mao, LJ; Wen, RM |
| 刊名 | CANCER BIOLOGY & THERAPY
 |
| 出版日期 | 2009 |
| 卷号 | 8期号:1页码:84-91 |
| 关键词 | RNAi hTERT oncolytic adenovirus renal cancer shRNAs apoptosis gene therapy |
| 通讯作者 | Zheng, JN (reprint author), Affiliated Hosp, Lab Urol, Xuzhou Med Coll, 99 W Huai Hai Rd, Xuzhou, Jiangsu, Peoples R China.,jnzheng@xzmc.edu.cn |
| 英文摘要 | RNA interference (RNAi) has been proved to be a powerful tool for gene knockdown purpose and holds a great promise for the treatment of cancer. Our previous study demonstrated that the reduction of hTERT expression by means of chemically synthesized siRNAs and shRNAs expressed from plasmid resulted in proliferation inhibition in human renal carcinoma cells. In this study, we constructed a novel oncolytic adenovirus-based shRNA expression system, ZD55-hTERT and to explore ZD55-hTERT-mediated RNAi for hTERT gene silencing. Our results showed that ZD55-hTERT could induce silencing of hTERT gene effectively, allow for efficient tumor-specific viral replication and induce the apoptosis of tumor cells effectively in vitro and in nude mice. We conclude that combining shRNA gene therapy and oncolytic virotherapy can enhance antitumor efficacy as a result of synergism between CRAd oncolysis and shRNA antitumor responses. |
| 学科主题 | Oncology |
| 类目[WOS] | Oncology |
| 关键词[WOS] | TELOMERASE ACTIVITY ; BLADDER-CANCER ; NECK-CANCER ; EXPRESSION ; ONYX-015 ; PROLIFERATION ; INTERFERENCE ; REPLICATION ; COMBINATION ; EFFICACY |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000264207500019 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1127]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zheng, JN,Pei, DS,Sun, FH,et al. Inhibition of renal cancer cell growth by oncolytic adenovirus armed short hairpin RNA targeting hTERT gene[J]. CANCER BIOLOGY & THERAPY,2009,8(1):84-91. |
| APA | Zheng, JN.,Pei, DS.,Sun, FH.,Zhang, BF.,Liu, XY.,...&Li, W.(2009).Inhibition of renal cancer cell growth by oncolytic adenovirus armed short hairpin RNA targeting hTERT gene.CANCER BIOLOGY & THERAPY,8(1),84-91. |
| MLA | Zheng, JN,et al."Inhibition of renal cancer cell growth by oncolytic adenovirus armed short hairpin RNA targeting hTERT gene".CANCER BIOLOGY & THERAPY 8.1(2009):84-91. |
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