中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Generation and application of human iPS cells

文献类型:期刊论文

作者Cui, C; Rao, LJ; Cheng, LZ; Xiao, L
刊名CHINESE SCIENCE BULLETIN
出版日期2009
卷号54期号:1页码:42260
关键词ES cell reprogramming iPS differentiation transplantation regenerative medicine
通讯作者Xiao, L (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Cell Bank Stem Cell bank,Lab Mol Cell Biol, Inst Biochem & Cell Biol,Key Lab Stem Cell Biol, Shanghai 200031, Peoples R China.,leixiao@sibs.ac.cn
英文摘要Human embryonic stem (ES) cells are capable of unlimited proliferation and maintenance of pluripotency in vitro; these properties may lead to potential applications in regenerative medicine. However, immune rejection hampers the allogenic application of human ES cells. Over-expression of several specific transcription factors has been used to reprogram human adult cells into induced pluripotent stem (iPS) cells, which are similar to hESCs in many aspects. The iPS technique makes it possible to produce patient-specific pluripotent stem cells for transplantation therapy without immune rejection. However, some challenges remain, including viral vector integration into the genome, the existence of exogenous oncogenic factors, and low induction efficiency. Here, we review recent advances in human iPS methodology, as well as remaining challenges and its potential applications.
学科主题Science & Technology - Other Topics
类目[WOS]Multidisciplinary Sciences
关键词[WOS]PLURIPOTENT STEM-CELLS ; HUMAN SOMATIC-CELLS ; DEFINED FACTORS ; IN-VITRO ; HUMAN FIBROBLASTS ; NUCLEAR TRANSFER ; MOUSE ; DIFFERENTIATION ; ADULT ; INDUCTION
收录类别SCI
语种英语
WOS记录号WOS:000263128300003
版本出版稿
源URL[http://202.127.25.143/handle/331003/1129]  
专题上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式
GB/T 7714
Cui, C,Rao, LJ,Cheng, LZ,et al. Generation and application of human iPS cells[J]. CHINESE SCIENCE BULLETIN,2009,54(1):42260.
APA Cui, C,Rao, LJ,Cheng, LZ,&Xiao, L.(2009).Generation and application of human iPS cells.CHINESE SCIENCE BULLETIN,54(1),42260.
MLA Cui, C,et al."Generation and application of human iPS cells".CHINESE SCIENCE BULLETIN 54.1(2009):42260.

入库方式: OAI收割

来源:上海生物化学与细胞生物学研究所

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