Generation and application of human iPS cells
文献类型：期刊论文
| 作者 | Cui, C; Rao, LJ; Cheng, LZ; Xiao, L |
| 刊名 | CHINESE SCIENCE BULLETIN
 |
| 出版日期 | 2009 |
| 卷号 | 54期号:1页码:42260 |
| 关键词 | ES cell reprogramming iPS differentiation transplantation regenerative medicine |
| 通讯作者 | Xiao, L (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Cell Bank Stem Cell bank,Lab Mol Cell Biol, Inst Biochem & Cell Biol,Key Lab Stem Cell Biol, Shanghai 200031, Peoples R China.,leixiao@sibs.ac.cn |
| 英文摘要 | Human embryonic stem (ES) cells are capable of unlimited proliferation and maintenance of pluripotency in vitro; these properties may lead to potential applications in regenerative medicine. However, immune rejection hampers the allogenic application of human ES cells. Over-expression of several specific transcription factors has been used to reprogram human adult cells into induced pluripotent stem (iPS) cells, which are similar to hESCs in many aspects. The iPS technique makes it possible to produce patient-specific pluripotent stem cells for transplantation therapy without immune rejection. However, some challenges remain, including viral vector integration into the genome, the existence of exogenous oncogenic factors, and low induction efficiency. Here, we review recent advances in human iPS methodology, as well as remaining challenges and its potential applications. |
| 学科主题 | Science & Technology - Other Topics |
| 类目[WOS] | Multidisciplinary Sciences |
| 关键词[WOS] | PLURIPOTENT STEM-CELLS ; HUMAN SOMATIC-CELLS ; DEFINED FACTORS ; IN-VITRO ; HUMAN FIBROBLASTS ; NUCLEAR TRANSFER ; MOUSE ; DIFFERENTIATION ; ADULT ; INDUCTION |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000263128300003 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1129]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Cui, C,Rao, LJ,Cheng, LZ,et al. Generation and application of human iPS cells[J]. CHINESE SCIENCE BULLETIN,2009,54(1):42260. |
| APA | Cui, C,Rao, LJ,Cheng, LZ,&Xiao, L.(2009).Generation and application of human iPS cells.CHINESE SCIENCE BULLETIN,54(1),42260. |
| MLA | Cui, C,et al."Generation and application of human iPS cells".CHINESE SCIENCE BULLETIN 54.1(2009):42260. |
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