Hippo signaling pathway and organ size control
文献类型：期刊论文
| 作者 | Zhang, L; Yue, T; Jiang, J |
| 刊名 | FLY
 |
| 出版日期 | 2009 |
| 卷号 | 3期号:1页码:68-73 |
| 关键词 | Hippo MST Yap Fat Yki TEAD Wts Lats NF2 Merlin |
| 通讯作者 | Jiang, J (reprint author), Univ Texas SW Med Ctr Dallas, Dept Dev Biol, 5323 Harry Hines Blvd, Dallas, TX 75390 USA.,jin.jiang@utsouthwestern.edu |
| 英文摘要 | Initially discovered in Drosophila, the Hippo (Hpo) pathway has been recognized as a conserved signaling pathway that controls organ size during development by restricting cell growth and proliferation and by promoting apoptosis. In addition, abnormal activities of several Hpo pathway components have been implicated in human cancer. Here, we review the current understanding of the molecular and cellular basis of Hpo signaling in development and tumorigenesis, and discuss how the Hpo pathway integrates spatial and temporal signals to control tissue growth and organ size. |
| 学科主题 | Biochemistry & Molecular Biology |
| 类目[WOS] | Biochemistry & Molecular Biology |
| 关键词[WOS] | TUMOR-SUPPRESSOR GENE ; REGULATE CELL-PROLIFERATION ; PROMOTES APOPTOSIS ; CONTACT INHIBITION ; GROWTH-CONTROL ; NEUROFIBROMATOSIS TYPE-2 ; DROSOPHILA HOMOLOG ; TEAD/TEF FAMILY ; PROTEIN-KINASE ; EXPANDED ACT |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000263028600009 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1130]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Zhang, L,Yue, T,Jiang, J. Hippo signaling pathway and organ size control[J]. FLY,2009,3(1):68-73. |
| APA | Zhang, L,Yue, T,&Jiang, J.(2009).Hippo signaling pathway and organ size control.FLY,3(1),68-73. |
| MLA | Zhang, L,et al."Hippo signaling pathway and organ size control".FLY 3.1(2009):68-73. |
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