Regulation of apoptosis of rbf mutant cells during Drosophila development
文献类型：期刊论文
| 作者 | Tanaka-Matakatsu, M; Xu, JH; Cheng, LP; Du, W |
| 刊名 | DEVELOPMENTAL BIOLOGY
 |
| 出版日期 | 2009 |
| 卷号 | 326期号:2页码:347-356 |
| 关键词 | Rb family protein Rbf hid Apoptosis Drosophila Eye development bantam |
| 通讯作者 | Du, W (reprint author), Univ Chicago, Ben May Dept Canc Res, 929 E 57th St, Chicago, IL 60637 USA.,wei@uchicago.edu |
| 英文摘要 | Inactivation of the retinoblastoma gene Rb leads to defects in cell proliferation, differentiation, or apoptosis, depending on specific cell or tissue types. To gain insights into the genes that call modulate the consequences of Rb inactivation, we carried out a genetic screen in Drosophila to identify mutations that affected apoptosis induced by inactivation of the Retinoblastoma-family protein (rbf) and identified a mutation that blocked apoptosis induced by rbf. We found this mutation to be a new allele of head involution defective (hid) and showed that hid expression is deregulated in rbf mutant cells in larval imaginal discs. We identified an enhancer that regulates hid expression in response to developmental cues as well as to radiation and demonstrated that this hid enhancer is directly repressed by RBF through an E2F binding site. These observations indicate that apoptosis of rbf mutant cells is mediated by an upregulation of hid. Finally, we showed that bantam, a miRNA that regulates hid translation, is expressed in the interommatidial cells in the larval eye discs and modulates the survival of rbf mutant cells. (c) 2008 Elsevier Inc. All rights reserved. |
| 学科主题 | Developmental Biology |
| 类目[WOS] | Developmental Biology |
| 关键词[WOS] | COMPENSATORY PROLIFERATION ; DISTINCT MECHANISMS ; MAMMALIAN-CELLS ; HEAD INVOLUTION ; EYE DEVELOPMENT ; CASPASE DRONC ; DEATH GENE ; WING DISC ; REAPER ; HID |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000263285200008 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1146]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Tanaka-Matakatsu, M,Xu, JH,Cheng, LP,et al. Regulation of apoptosis of rbf mutant cells during Drosophila development[J]. DEVELOPMENTAL BIOLOGY,2009,326(2):347-356. |
| APA | Tanaka-Matakatsu, M,Xu, JH,Cheng, LP,&Du, W.(2009).Regulation of apoptosis of rbf mutant cells during Drosophila development.DEVELOPMENTAL BIOLOGY,326(2),347-356. |
| MLA | Tanaka-Matakatsu, M,et al."Regulation of apoptosis of rbf mutant cells during Drosophila development".DEVELOPMENTAL BIOLOGY 326.2(2009):347-356. |
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