Luteolin inhibits proliferation and affects the function of stimulated rat synovial fibroblasts
文献类型：期刊论文
| 作者 | Hou, YA; Wu, JC; Huang, Q; Guo, LH |
| 刊名 | CELL BIOLOGY INTERNATIONAL
 |
| 出版日期 | 2009 |
| 卷号 | 33期号:2页码:135-147 |
| 关键词 | Rheumatoid arthritis (RA) Synovial fibroblast (SFB) Luteolin Collagen-induced arthritis (CIA) Proliferation |
| 通讯作者 | Guo, LH (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Room 901,Cell Biol Bldg,320 Yueyang Rd, Shanghai 200031, Peoples R China.,lhguo@sibs.ac.cn |
| 英文摘要 | Hyperproliferation of synovial fibroblasts is considered to be a pivotal event in the pathogenesis of rheumatoid arthritis (RA). Luteolin, a flavonoid, inhibits the proliferation of synovial fibroblasts in collagen-induced arthritic rats. Treatment with luteolin also decreases the secretion of matrix metalloprotease-1 and -3 and the expression of IL-6, IL-8, IL-15, and TGF-beta. Luteolin treatment caused a delay of cells in the G(2)/M phase. Interestingly, combination treatment with luteolin and TNF-alpha exhibited a synergistic inhibitory effect in all experiments. Western blotting demonstrated that treatment with luteolin alone or combined with TNF-alpha inhibited the MAPK/ERKs and PI3K-Akt pathways. These results indicate that luteolin inhibits the proliferation and partially blocks the pathogenic function of synovial fibroblasts in rheumatoid arthritis. (C) 2008 International Federation for Cell Biology. Published by Elsevier Ltd. All rights reserved. |
| 学科主题 | Cell Biology |
| 类目[WOS] | Cell Biology |
| 关键词[WOS] | COLLAGEN-INDUCED ARTHRITIS ; TUMOR-NECROSIS-FACTOR ; CELL-CYCLE PROGRESSION ; RHEUMATOID-ARTHRITIS ; TNF-ALPHA ; SYNOVIOCYTES ; FLAVONOIDS ; APOPTOSIS ; EXPRESSION ; DISEASES |
| 收录类别 | SCI |
| 语种 | 英语 |
| WOS记录号 | WOS:000262980300002 |
| 版本 | 出版稿 |
| 源URL | [http://202.127.25.143/handle/331003/1149]  |
| 专题 | 上海生化细胞研究所_上海生科院生化细胞研究所 |
| 推荐引用方式 GB/T 7714 | Hou, YA,Wu, JC,Huang, Q,et al. Luteolin inhibits proliferation and affects the function of stimulated rat synovial fibroblasts[J]. CELL BIOLOGY INTERNATIONAL,2009,33(2):135-147. |
| APA | Hou, YA,Wu, JC,Huang, Q,&Guo, LH.(2009).Luteolin inhibits proliferation and affects the function of stimulated rat synovial fibroblasts.CELL BIOLOGY INTERNATIONAL,33(2),135-147. |
| MLA | Hou, YA,et al."Luteolin inhibits proliferation and affects the function of stimulated rat synovial fibroblasts".CELL BIOLOGY INTERNATIONAL 33.2(2009):135-147. |
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