中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Low-Grade Fibromyxoid Sarcoma Versus Fibromatosis: A Comparative Study of Clinicopathological and Immunohistochemical Features

文献类型:期刊论文

作者Meng, GZ; Zhang, HY; Bu, H; Geng, JG
刊名DIAGNOSTIC CYTOPATHOLOGY
出版日期2009
卷号37期号:2页码:96-102
关键词low-grade fibromyxoid sarcoma fibromatosis diagnosis differential
通讯作者Meng, GZ (reprint author), Chinese Acad Sci, Shanghai Inst Biol Sci, Inst Biochem & Cell Biol, Shanghai 200031, Peoples R China.,gzmeng@sibs.ac.cn
英文摘要We have studied 11 cases of low-grade fibromyxoid sarcoma (LGFMS) and 15 cases of fibromatosis with respect to clinicopathological features and immunohistochemical expression of Ki-67, nm23, cyclinD1, and p53, in order to investigate the differential diagnosis between this two groups. Formalin-fixed, paraffin-embedded sections from 11 cases of LGFMS and 15 cases of fibromatosis were studied histologically and immunohistochemically. The immunostainings were semiquantitatively evaluated using the Allred score system. Microscopically, LGFMS was composed of bland spindle cells arranged in a whorled pattern showing alternating myxoid zones and fibrous stroma zones with prominent arcade curvilinear capillaries. Cytological atypia, mitotic figures, and tumor necrosis were absent in all 11 cases of LGFMS. In contrast, fibromatosis was less cellular and more fascicular, containing more collagen and showing no alternating fibrous and myxoid zones as compared with LGFMS. The immunostaining scores of nm23 in LGFMS were significantly lower than that in fibromatosis. The immunostaining scores of Ki-67 p53, and cyclinD1 in LGFMS were significantly higher than that in fibromatosis. Thus, we consider that LGFMS can be distinguished from fibromatosis by clinicopathological features, and assessments of the immunohistochemical expression level of cyclinD1, p53, nm23, and Ki-67 are helpful in the differential diagnosis. Diagn. Cytopathol. 2009;37:96-102. (C) 2008 Wiley-Liss, Inc.
学科主题Medical Laboratory Technology; Pathology
类目[WOS]Medical Laboratory Technology ; Pathology
关键词[WOS]SPINDLE-CELL TUMOR ; GIANT ROSETTES ; SYNOVIAL SARCOMA ; P53 ; EXPRESSION ; CANCER ; MULTIFACTORIAL ; PROLIFERATION ; NEOPLASMS ; BENIGN
收录类别SCI
语种英语
WOS记录号WOS:000262905300005
版本出版稿
源URL[http://202.127.25.143/handle/331003/1152]  
专题上海生化细胞研究所_上海生科院生化细胞研究所
推荐引用方式
GB/T 7714
Meng, GZ,Zhang, HY,Bu, H,et al. Low-Grade Fibromyxoid Sarcoma Versus Fibromatosis: A Comparative Study of Clinicopathological and Immunohistochemical Features[J]. DIAGNOSTIC CYTOPATHOLOGY,2009,37(2):96-102.
APA Meng, GZ,Zhang, HY,Bu, H,&Geng, JG.(2009).Low-Grade Fibromyxoid Sarcoma Versus Fibromatosis: A Comparative Study of Clinicopathological and Immunohistochemical Features.DIAGNOSTIC CYTOPATHOLOGY,37(2),96-102.
MLA Meng, GZ,et al."Low-Grade Fibromyxoid Sarcoma Versus Fibromatosis: A Comparative Study of Clinicopathological and Immunohistochemical Features".DIAGNOSTIC CYTOPATHOLOGY 37.2(2009):96-102.

入库方式: OAI收割

来源:上海生物化学与细胞生物学研究所

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